1201786-19-7Relevant academic research and scientific papers
3-Arylamino and 3-alkoxy-nor-β-lapachone derivatives: Synthesis and cytotoxicity against cancer cell lines
Da Silva Jr., Eufranio N.,De Deus, Clara F.,Cavalcanti, Bruno C.,Pessoa, Cláudia,Costa-Lotufo, Letícia V.,Montenegro, Raquel C.,De Moraes, Manoel O.,Pinto, Maria Do Carmo F. R.,De Simone, Carlos A.,Ferreira, Vitor F.,Goulart, Marilia O. F.,Andrade, Carlos Kleber Z.,Pinto, Ant?nio V.
supporting information; experimental part, p. 504 - 508 (2010/05/02)
Several 3-arylamino and 3-alkoxy-nor-β-lapachone derivatives were synthesized in moderate to high yields and found to be highly potent against cancer cells SF295 (central nervous system),HCT8 (colon), MDA-MB435 (melanoma), and HL60 (leukemia), with ICsub
The evaluation of quinonoid compounds against Trypanosoma cruzi: Synthesis of imidazolic anthraquinones, nor-β-lapachone derivatives and β-lapachone-based 1,2,3-triazoles
da Silva Júnior, Eufranio N.,Guimar?es, Tiago T.,Menna-Barreto, Rubem F.S.,Pinto, Maria do Carmo F.R.,de Simone, Carlos A.,Pessoa, Claudia,Cavalcanti, Bruno C.,Sabino, José R.,Andrade, Carlos Kleber Z.,Goulart, Marilia O.F.,de Castro, Solange L.,Pinto, Ant?nio V.
scheme or table, p. 3224 - 3230 (2010/07/08)
In continuing our screening program of naphthoquinone activity against Trypanosoma cruzi, the aetiological agent of Chagas' disease, new β-lapachone-based 1,2,3-triazoles, 3-arylamino-nor-β-lapachones, 3-alkoxy-nor-β-lapachones and imidazole anthraquinones were synthesised and evaluated against bloodstream trypomastigote forms of the parasite. Compounds 2,2-dimethyl-3-(2,4-dibromophenylamino)-2,3-dihydro-naphtho[1,2-b]furan-4,5-dione, IC50/24 h 24.9 ± 7.4 and 4-azido-3-bromo-2,2-dimethyl-3,4-dihydro-2H-benzo[h]chromene-5,6-dione with 23.4 ± 3.8 μM showed a trypanosomicidal activity higher than benznidazole. These results demonstrate the potential of naphthoquinone derivatives as novel structures for the development of alternative drugs for Chagas' disease.
