1201786-20-0Relevant academic research and scientific papers
Liposomes containing 3-arylamino-nor-β-lapachone derivative: Development, characterization, and in vitro evaluation of the cytotoxic activity
, (2021)
This study aimed to encapsulate the novel synthetic naphthoquinone ENSJ39 in liposomes, characterize them, and evaluate their in vitro cytotoxic activity in different cancer cell lines. Liposomes were obtained by the dried-lipid film hydration method, and
3-Arylamino and 3-alkoxy-nor-β-lapachone derivatives: Synthesis and cytotoxicity against cancer cell lines
Da Silva Jr., Eufranio N.,De Deus, Clara F.,Cavalcanti, Bruno C.,Pessoa, Cláudia,Costa-Lotufo, Letícia V.,Montenegro, Raquel C.,De Moraes, Manoel O.,Pinto, Maria Do Carmo F. R.,De Simone, Carlos A.,Ferreira, Vitor F.,Goulart, Marilia O. F.,Andrade, Carlos Kleber Z.,Pinto, Ant?nio V.
supporting information; experimental part, p. 504 - 508 (2010/05/02)
Several 3-arylamino and 3-alkoxy-nor-β-lapachone derivatives were synthesized in moderate to high yields and found to be highly potent against cancer cells SF295 (central nervous system),HCT8 (colon), MDA-MB435 (melanoma), and HL60 (leukemia), with ICsub
The evaluation of quinonoid compounds against Trypanosoma cruzi: Synthesis of imidazolic anthraquinones, nor-β-lapachone derivatives and β-lapachone-based 1,2,3-triazoles
da Silva Júnior, Eufranio N.,Guimar?es, Tiago T.,Menna-Barreto, Rubem F.S.,Pinto, Maria do Carmo F.R.,de Simone, Carlos A.,Pessoa, Claudia,Cavalcanti, Bruno C.,Sabino, José R.,Andrade, Carlos Kleber Z.,Goulart, Marilia O.F.,de Castro, Solange L.,Pinto, Ant?nio V.
scheme or table, p. 3224 - 3230 (2010/07/08)
In continuing our screening program of naphthoquinone activity against Trypanosoma cruzi, the aetiological agent of Chagas' disease, new β-lapachone-based 1,2,3-triazoles, 3-arylamino-nor-β-lapachones, 3-alkoxy-nor-β-lapachones and imidazole anthraquinones were synthesised and evaluated against bloodstream trypomastigote forms of the parasite. Compounds 2,2-dimethyl-3-(2,4-dibromophenylamino)-2,3-dihydro-naphtho[1,2-b]furan-4,5-dione, IC50/24 h 24.9 ± 7.4 and 4-azido-3-bromo-2,2-dimethyl-3,4-dihydro-2H-benzo[h]chromene-5,6-dione with 23.4 ± 3.8 μM showed a trypanosomicidal activity higher than benznidazole. These results demonstrate the potential of naphthoquinone derivatives as novel structures for the development of alternative drugs for Chagas' disease.
