1201799-41-8

Upstream product

• 100487-78-3 5-chloro-3-diazo-1,3-dihydro-2H-indol-2-one 
• 459-57-4 4-fluorobenzaldehyde 
• 17630-76-1 5-chloroindole 2,3-dione 

Downstream Products

• 1312785-25-3 3-(5-chloro-2-oxoindolin-3-ylideneamino)-2-(4-fluorophenyl)thiazolidin-4-one 
• 1312785-45-7 5-chloro-3-[3-chloro-2-(4-fluorophenyl)-4-oxoazetidin-1-ylimino]indolin-2-one 

Relevant academic research and scientific papers

Synthesis leishmanicidal activities of bis-Schiff bases of isatins

Twenty seven (27) derivatives of bis-Schiff bases of isatins 1-27 were studied for their leishmanicidal potential. Out of twenty seven (27) analogs, five exhibited varying degree of leishmanicidal activity with IC50 values 44.86 ± 0.66, 65.27 ±

Superoxide respiratory burst inhibitory activity of bis-schiff bases of Isatins

Bis-Schiff bases 1-27 were synthesized and evaluated for their anti-inflammatory activity and possible cytotoxicity. Compounds 1-27 showed a varying degree of respiratory burst inhibitory activity with IC50 values between 242.97 - 652.12 μM. Co

Synthesis and antimicrobial activity of 5-chloroindoline-2,3-dione derivatives

A series of 3-(5-chloro-2-oxoindolin-3-ylideneamino)-2-arylthiazolidin-4- ones 4a-k and 5-chloro-3-(3- chloro-2-oxo-4-arylazetidin-1-ylimino)indolin-2- ones 5a-k was synthesized. The structures of final compounds were confirmed by analytical (C, H, N) and spectral (FT-IR, 1H NMR, 13C NMR and Mass) data. The synthesized compounds were screened for possible antibacterial and antifungal activity. Compounds 4c, 4f, 4g, 4h, 4i, 4j, 5c, 5f, 5g, 5h, 5i and 5j showed substantially significant activity. Springer Science+Business Media, LLC 2011.

Synthesis of bis-Schiff bases of isatins and their antiglycation activity

Bis-Schiff bases 1-27 have been synthesized and their in vitro antiglycation potential has been evaluated. Compounds 21 (IC50 = 243.95 ± 4.59 μM), 20 (IC50 = 257.61 ± 5.63 μM), and 7 (IC50 = 291.14 ± 2.53 μM) showed an exc