1201827-41-9Relevant academic research and scientific papers
Synthesis and Application of Substituted 1,16-Dihydroxytetraphenylenes in Catalytic Asymmetric Allylboration of Ketones
Chai, Guo-Li,Zhu, Bo,Chang, Junbiao
, p. 120 - 127 (2019)
The synthesis and application of a newly designed C2-symmetric chiral-substituted 1,16-dihedroxytetraphenylene (DHTP) is reported. Efficient syntheses of enantiopure substituted DHTP were accomplished, and these enantiopure compounds were used as organocatalysts in asymmetric allylboration of ketones under very mild conditions. Accordingly, several tertiary alcohols were generated in moderate to good yields with up to 99% ee by using the catalyst (S)-2,15-Br2-DHTP. A gram-scale reaction was achieved in 99% yield with 96% ee.
The mechanism and an improved asymmetric allylboration of ketones catalyzed by chiral biphenols
Barnett, David S.,Moquist, Philip N.,Schaus, Scott E.
supporting information; experimental part, p. 8679 - 8682 (2010/02/28)
Giving it a boost: A mechanistic study of the enantioselective asymmetric titled reaction with allyldiisopropoxyborane catalyzed by chiral biphenols revealed a key ligand exchange process which liberates isopropyl alcohol. The addition of iPrOH to the rea
