1201848-93-2Relevant academic research and scientific papers
Synthesis of a Resorcylic Acid Lactone (RAL) library using fluorous-mixture synthesis and profile of its selectivity against a panel of kinases
Jogireddy, Rajamalleswaramma,Dakas, Pierre-Yves,Valot, Gaelle,Barluenga, Sofia,Winssinger, Nicolas
supporting information; experimental part, p. 11498 - 11506 (2010/05/02)
A library of resorcylic acid lactones (RAL) containing a cis-enone moiety targeting kinases bearing a cysteine residue within the ATP-binding pocket was prepared using a fluorous-mixture synthesis and evaluated against a panel of 19 kinases thus providing important structure-activity trends. Two new analogues were then profiled for their selectivity against a panel of 402 kinases providing the broadest evaluation of this pharmacophores' selectivity.
