1201898-67-0Relevant academic research and scientific papers
Substituent effects on reactive oxygen species (ROS) generation by hydroquinones
Dharmaraja, Allimuthu T.,Jain, Charu,Chakrapani, Harinath
, p. 9413 - 9417 (2014)
In order to understand the structural aspects of stabilization of hydroquinones and their ability to generate reactive oxygen species (ROS), we designed and synthesized a series of 6-aryl-2,3-dihydro-1,4-benzoquinones. These compounds equilibrate with the corresponding 6-aryl-1,4-dihydroxybenzenes in an organic medium; a linear free energy relationship analysis gave ρ = +2.37, suggesting that this equilibrium was sensitive to electronic effects. The propensity of the compound to enolize appears to determine ROS-generating capability, thus offering scope for tunable ROS generation.
Total synthesis of two γ-butyrolactone containing compounds (Z,11S)-3,4-trans-11-hydroxy-3-methyldodec-cis-6-en-4-olide and (Z)-3,4-trans-11-oxo-3-methyldodec-cis-6-en-4-olide
Nomula, Rajesh,Raju, Galla,Radha Krishna, Palakodety
, p. 5976 - 5978 (2014)
The first total synthesis of (Z,11S)-3,4-trans-11-hydroxy-3-methyldodec-cis-6-en-4-olide and (Z)-3,4-trans-11-oxo-3-methyldodec-cis-6-en-4-olide was accomplished using Jacobsen hydrolytic kinetic resolution, Ohira-Bestmann reaction, regioselective alkyne
Synthesis of (R)-coniine and (S)-coinicine via organocatalytic-aminoxyl- ation of an aldehyde
Kondekar, Nagendra B.,Kumar, Pradeep
experimental part, p. 3105 - 3112 (2010/11/02)
A short and efficient synthesis of the indolizidine alkaloid (S)-coinicine has been achieved using organocatalytic sequential-aminoxylation and Horner-Wadsworth-Emmons olefination of an aldehyde catalyzed by l-proline. Similarly, a common organocatalytic-aminoxylation route has been developed for the asymmetric synthesis of both (R)-coniine and (S)-coinicine. Georg Thieme Verlag Stuttgart - New York.
First asymmetric total synthesis of aspinolide A
Chowdhury, Partha Sarathi,Gupta, Priti,Kumar, Pradeep
scheme or table, p. 7018 - 7020 (2010/02/28)
The first total synthesis of aspinolide A has been achieved using ring-closing metathesis as a key step. The stereogenic centers were generated by means of hydrolytic kinetic resolution (HKR) of racemic epoxides.
