1201913-85-0Relevant academic research and scientific papers
Rapid access towards follow-up NOP receptor agonists using a knowledge based approach
Palin, Ronald,Clark, John K.,Evans, Louise,Feilden, Helen,Fletcher, Dan,Hamilton, Niall M.,Houghton, Andrea K.,Jones, Philip S.,McArthur, Duncan,Montgomery, Brian,Ratcliffe, Paul D.,Smith, Alasdair R.C.,Sutherland, Aaron,Weston, Mark A.,Wishart, Grant
scheme or table, p. 6441 - 6446 (2010/05/02)
A knowledge based approach has been adopted to identify novel NOP receptor agonists with simplified hydrophobes. Substitution of the benzimidazol-2-one piperidine motif with a range of hydrophobic groups and pharmacophore guided bio-isosteric replacement
