1201938-07-9

Upstream product

• 3682-71-1 2-phenyl-2H-indazole 
• 5798-75-4 Ethyl 4-bromobenzoate 
• 51934-41-9 4-iodobenzoic acid ethyl ester 
• 83536-13-4 bis(4-ethoxycarbonylphenyl)acetylene 
• 20972-43-4 trans-azoxybenzene 

Relevant academic research and scientific papers

Rh(III)-Catalyzed [4 + 1]-Annulation of Azoxy Compounds with Alkynes: A Regioselective Approach to 2H-Indazoles

A rhodium-catalyzed regioselective C-H activation/cyclization of azoxy compounds with alkynes has been disclosed to construct a variety of 2H-indazoles. A [4 + 1]-cycloaddition rather than a normal [4 + 2] mode is observed in the process of cyclative capture along with an oxygen-atom transfer and a C≡C triple bond cleavage. This protocol features a broad substrate scope, a good functional group tolerance, and an exclusive regioselectivity.

Direct arylations of 2H-Lndazoles on water

(Figure presented) The efficient palladium-catalyzed synthesis of a range of substituted 2H-lndazoles via C-H arylation Is reported. Reactions are performed on water and provide a direct and mild route toward 2,3-diaryl Indazoles of widespread biological significance.