1201944-90-2Relevant academic research and scientific papers
Discovery of the first known small-molecule inhibitors of heme-regulated eukaryotic initiation factor 2α (HRI) kinase
Rosen, Mark D.,Woods, Craig R.,Goldberg, Steven D.,Hack, Michael D.,Bounds, A. Dawn,Yang, Young,Wagaman, Pamela C.,Phuong, Victor K.,Ameriks, Angela P.,Barrett, Terrance D.,Kanelakis, Kimon C.,Chang, Jui,Shankley, Nigel P.,Rabinowitz, Michael H.
scheme or table, p. 6548 - 6551 (2010/06/14)
A series of indeno[1,2-c]pyrazoles were discovered to be the first known inhibitors of heme-regulated eukaryotic initiation factor 2α (HRI) kinase. The synthesis, structure-activity relationship profile, and in-vitro pharmacological characterization of th
