120199-41-9

Upstream product

• 58759-08-3 (thienyl-3) glyoxal 
• 91793-49-6 S-(+)-(thienyl-3)-2 cyclohexyl-2 hydroxy-2 ethanal 
• 91741-38-7 acide S-(+)-(thienyl-3)-2 cyclohexyl-2 hydroxy-2 acetique 
• 91704-70-0 (+)-(thenoyl-3)-2 phenyl-3 diazabicyclo-1,3<3,3,O>octane 
• 3193-02-0 (+/-)-2-cyclohexyl-2-hydroxy-2-(3-thienyl)ethanoic acid 
• 1468-83-3 1-(thiophen-3-yl)-ethanone 

Relevant academic research and scientific papers

Dedoublement et determination de la configuration absolue des enantiomeres de l'acide (thienyl-3)-2 cyclohexyl-2 hydroxy-2 acetique. Application a la synthese d'esters anticholinergiques du quinuclidinol-3

Enantiomeric 2-(3-thienyl)-2-cyclohexyl-2-hydroxy acetic acids 1 were obtained by the resolution of (+/-)-1 using (+)- and (-)-ephedrine as the resolving agents, and by asymmetric synthesis; (+)-1 was assigned S absolute configuration (i) by comparing the circular dichroism spectra of a series of derivatives of 1 with those of the corresponding derivatives of S-(+)-2-phenyl-2-cyclohexyl-2-hydroxy acetic acid 1', and (ii) by application of the quasi-racemate method.On transesterification of the methyl esters of 1, R-(+)-2 and S-(-)-2, with R-(-)- or S-(+)-1-azabicyclo-3-octanol (or 3-quinuclidinol), the four diastereoisomers of 3-quinuclidinyl 2-(3-thienyl)-2-cyclohexyl-2-hydroxy-acetate were obtained, i.e., (+)-2R, 3'S-6, (-)-2S, 3'R-6, (+)-2R, 3'R-7, and (-)-2S, 3'S-7.These compounds exhibited anticholinergic activity.