1202055-34-2 Usage
General Description
NMS-P715 is a chemical compound known for its properties as an inhibitor for the protein kinase MPS1, which is involved in cell division processes, mainly in mitosis. It acts by preventing MPS1 activity, thereby interfering with spindle assembly checkpoints and causing inaccurate chromosomal segregation. The inhibition of MPS1 by NMS-P715 may disturb tumor cells' division process, which can eventually lead to cell death. Therefore, NMS-P715 can be potentially used as targeted therapy in cancer treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 1202055-34-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,0,2,0,5 and 5 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1202055-34:
(9*1)+(8*2)+(7*0)+(6*2)+(5*0)+(4*5)+(3*5)+(2*3)+(1*4)=82
82 % 10 = 2
So 1202055-34-2 is a valid CAS Registry Number.
1202055-34-2Relevant articles and documents
Synthesis and SAR of new pyrazolo[4,3-h]quinazoline-3-carboxamide derivatives as potent and selective MPS1 kinase inhibitors
Caldarelli, Marina,Angiolini, Mauro,Disingrini, Teresa,Donati, Daniele,Guanci, Marco,Nuvoloni, Stefano,Posteri, Helena,Quartieri, Francesca,Silvagni, Marco,Colombo, Riccardo
, p. 4507 - 4511 (2011/09/12)
The synthesis and SAR of a series of novel pyrazolo-quinazolines as potent and selective MPS1 inhibitors are reported. We describe the optimization of the initial hit, identified by screening the internal library collection, into an orally available, potent and selective MPS1 inhibitor.
