1202160-01-7Relevant articles and documents
Isoquinoline-based analogs of the cancer drug clinical candidate tipifarnib as anti-Trypanosoma cruzi agents
Chennamaneni, Naveen Kumar,Arif, Jenifer,Buckner, Frederick S.,Gelb, Michael H.
supporting information; experimental part, p. 6582 - 6584 (2010/06/12)
We developed a synthetic route to prepare isoquinoline analogs of the cancer drug clinical candidate tipifarnib. We show that these compounds kill Trypanosoma cruzi amastigotes grown in mammalian host cells at concentrations in the low nanomolar range. Th