1202171-77-4Relevant academic research and scientific papers
Diastereoselective α-Fluorination of N- tert-Butanesulfinyl Imidates
Huang, Wei,Yao, Yun,Xu, Yan-Jun,Lu, Chong-Dao
, p. 14777 - 14785 (2018)
A diastereoselective α-fluorination of N-tert-butanesulfinyl imidates was developed. Deprotonation of N-tert-butanesulfinyl imidates with lithium hexamethyldisilazide generates aza-enolates that can be intercepted, with excellent diastereocontrol, by the inexpensive electrophilic fluorinating agent NFSI. This protocol was applied to the preparation of synthetically useful trans-2-fluoro-cyclohexamine with high enantiomeric purity (99.5% ee).
