1202205-44-4Relevant academic research and scientific papers
An efficient synthesis of (±)-grandisol featuring 1,5-enyne metathesis
Graham, Thomas J. A.,Gray, Erin E.,Burgess, James M.,Goess, Brian C.
supporting information; experimental part, p. 226 - 228 (2010/04/24)
(Chemical Equation Presented) An eight-step synthesis of (±)-grandisol features a key sequence involving a high-yielding, microwave-assisted enyne metathesis to yield a 1-alkenylcyclobutene that is semihydrogenated to yield a silyl-protected grandisol. Metathesis catalyst screens revealed an intriguing trend whereby substrate conversion correlated strongly with the identity of the ligands on the catalyst. In addition, new reactivity of 1-alkenylcyclobutenes toward hydrogenation is described.
