120221-69-4

Basic information

• Product Name: 1-Indolizinecarboxylic acid, 3-acetyl-
• Synonyms: 1-Indolizinecarboxylic acid, 3-acetyl-;3-Acetylindolizine-1-carboxylic acid
• CAS NO: 120221-69-4
• Molecular Formula: C11H9NO3
• Molecular Weight: 203.19406
• Mol File: 120221-69-4.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 1.31±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 1.90±0.41(Predicted)
• CAS DataBase Reference: 1-Indolizinecarboxylic acid, 3-acetyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Indolizinecarboxylic acid, 3-acetyl-(120221-69-4)
• EPA Substance Registry System: 1-Indolizinecarboxylic acid, 3-acetyl-(120221-69-4)

Safety Data

• Hazardous Substances Data: 120221-69-4(Hazardous Substances Data)

Usage

General Description

3-Acetyl-1-Indolizinecarboxylic acid is a chemical compound that belongs to the class of chemicals known as indolizines. These are polycyclic aromatic compounds containing a fused pyridine and pyrrole ring. In 3-Acetyl-1-Indolizinecarboxylic acid, an acetyl group is attached to the third atom of the indolizine group and a carboxylic acid group is attached to the first atom. This chemical is not commonly found in the scientific literature and therefore its applications and properties are not widely documented. However, the indolizine group is known to have bioactive properties and, as such, this compound can have potential use in the field of medicine or drug discovery.

Upstream product

• 61860-47-7 methyl 3-acetylindolizine-1-carboxylate 
• 42508-60-1 1-(2-oxopropyl)pyridinium chloride 
• 110-86-1 pyridine 

Relevant articles and documents

Indolizine-phenothiazine hybrids as the first dual inhibitors of tubulin polymerization and farnesyltransferase with synergistic antitumor activity

In the incessant search for innovative cancer control strategies, this study was devoted to the design, synthesis and pharmacological evaluation of dual inhibitors of farnesyltransferase and tubulin polymerization (FTI/MTIs). A series of indolizine-phenothiazine hybrids 16 (amides) and 17 (ketones) has been obtained in a 4-step procedure. The combination of the two heterocycles provided potent tubulin polymerization inhibitors with similar efficiency as the reference phenstatin and (-)-desoxypodophyllotoxin. Ketones 17 were also able to inhibit human farnesyltransferase (FTase) in vitro. Interestingly, three molecules 17c, 17d and 17f were very effective against both considered biological targets. Next, nine indolizine-phenothiazine hybrids 16c, 16f, 17a-f and 22b were evaluated for their cell growth inhibition potential on the NCI-60 cancer cell lines panel. Ketones 17a-f were the most active and displayed promising cellular activities. Not only they arrested the cell growth of almost all tested cancer cells, but they displayed cytotoxicity potential with GI50 values in the low nanomolar range. The most sensitive cell lines upon treatment with indolizine-phenothiazine hybrids were NCI-H522 (lung cancer), COLO-205 and HT29 (colon cancer), SF-539 (human glioblastoma), OVCAR-3 (ovarian cancer), A498 (renal cancer) and especially MDA-MB-435 (melanoma). Demonstrating the preclinical effectiveness of these dual inhibitors can be crucial. A single dual molecule could induce a synergy of antitumor activity, while increasing the effectiveness and reducing the toxicity of the classical combo treatments currently used in chemotherapy.