1202240-63-8Relevant articles and documents
Novel thienopyrimidine and thiazolopyrimidine kinase inhibitors with activity against Tie-2 in vitro and in vivo
Luke, Richard W.A.,Ballard, Peter,Buttar, David,Campbell, Leonie,Curwen, Jon,Emery, Steve C.,Griffen, Alison M.,Hassall, Lorraine,Hayter, Barry R.,Jones, Cliff D.,McCoull, William,Mellor, Martine,Swain, Mike L.,Tucker, Julie A.
, p. 6670 - 6674 (2009)
The SAR and improvement in potency against Tie2 of novel thienopyrimidine and thiazolopyrimidine kinase inhibitors are reported. The crystal structure of one of these compounds bound to the Tie-2 kinase domain is consistent with the SAR. These compounds h
