120225-54-9 Usage
Uses
Used in Neuronal Transmission Research:
CGS 21680 is used as a research tool for studying neuronal transmission, particularly in the context of adenosine A2 receptor activation. It helps researchers understand the role of adenosine in the central nervous system and its potential therapeutic applications.
Used in Respiratory Research:
In the field of respiratory research, CGS 21680 is used to investigate the effects of adenosine A2 receptor activation on respiratory function. This can provide insights into the potential use of adenosine receptor agonists in treating respiratory disorders.
Used in Adenosine A2A Receptor Research:
CGS 21680 is used as a selective agonist for the adenosine A2A receptor, allowing researchers to study the actions and mechanisms of this receptor in cells and tissues. This can lead to a better understanding of the role of A2A receptors in various physiological processes and the development of targeted therapies.
Used in Coronary Flow Studies:
CGS 21680 has been shown to effectively increase coronary flow, making it a useful compound in studying the cardiovascular effects of adenosine receptor activation. This can contribute to the development of treatments for conditions related to coronary blood flow.
Used in Electrophysiological Activity Research:
In hippocampal slices, CGS 21680 acts as a weak agonist on both preand postsynaptic measures of electrophysiological activity. This makes it a valuable tool for studying the effects of adenosine receptor activation on synaptic transmission and neuronal communication.
Biological Activity
cgs 21680 is a selective agonists of a2 adenosine receptor with ic50 value of 22nm [1].cgs 21680 is found to be potent and selective adenosine a2 receptor agonists. in a radioligand binding in vitro assay, cgs 21680 binds a2 receptor with ic50 value of 22nm and the a1/a2 ratio is 141, in the perfused rat heart model, cgs 21680 can increase coronary flow with greater ec25 value than 1000nm. it shows a good separation between its ability to induce vasorelaxation and bradycardia. cgs 21680 also has potent effect on blood pressure in vivo with ec25 value of 9μg/kg and it can induce an increase in heart rate [1].it is reported that cgs 21680 also has the potency of anti-inflammatory. it can reduce the development of acute lung inflammation in a mouse model of carrageenan-induced pleurisy. in both prior and post-treatment, cgs 21680 can reduce the number of inflammatory cells and the degree of lung injury [2].
references
[1] alan j. hutchison, randy l. webb, howard h. oei, geetha r. ghai, mark b. zimmerman and michael williams. cgs 21680c, an a2 selective adenosine receptor agonist with preferential hypotensive activity. the journal of pharmacology and experimental therapeutics. 1989, 25 (1): 47-55.[2] daniela impellizzeri, rosanna di paola, emanuela esposito, emanuela mazzon, irene paterniti, alessia melani, placido bramanti, felicita pedata, salvatore cuzzocrea. cgs 21680, an agonist of the adenosine (a2a) receptor, decreases acute lung inflammation. european journal of pharmacology. 2011, 68: 305-316.
Check Digit Verification of cas no
The CAS Registry Mumber 120225-54-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,0,2,2 and 5 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 120225-54:
(8*1)+(7*2)+(6*0)+(5*2)+(4*2)+(3*5)+(2*5)+(1*4)=69
69 % 10 = 9
So 120225-54-9 is a valid CAS Registry Number.
