120230-88-8

Upstream product

• 132560-61-3 E-3-p-toluenesulfonylmethylidene phthalide 
• 132560-54-4 Z-p-toluenesulfonylmethylidene phthalide 
• 87-41-2 2-benzofuran-1(3H)-one 
• 132560-53-3 3-(p-toluenesulfonylmethylidene)phthalan 
• 3185-99-7 Methyl p-tolyl sulfone 
• 120230-87-7 1-(2-bromophenyl)-2-tosylethan-1-one 
• 132560-55-5 3-Hydroxy-3-(toluene-4-sulfonylmethyl)-3H-isobenzofuran-1-one 

Downstream Products

• 132560-58-8 3-p-toluenesulfonylmethylidene-isoindole-1-one 

Relevant academic research and scientific papers

Novel Lactam Synthesis by Use of a Combination System of Carbonylation and Nitrogenation

An amide unit was constructed from aryl halide and titanium-isocyanate complex prepared from TiCl4 under atmospheric pressure of molecular nitrogen and carbon monoxide in the presence of a palladium catalyst.With this combination system of carbonylation and nitrogenation, isoindolinone and quinazolinone derivatives were synthesized from o-halophenyl alkyl ketone in one step.The reaction proceeds through the oxidative addition of enol lactone, generated by palladium-catalyzed carbonylation to o-halophenyl alkyl ketone, to titanium-isocyanate complex.

Incorporation of molecular nitrogen into organic compounds IV. Novel lactam synthesis by nitrogenation of enol lactones

Enol lactones 7, which are readily prepared from o-haloacetophenone derivatives 15 by palladium-catalyzed carbonylation, react with the titanium-isocyanate complex (1) generated by fixation of CO2 with titanium-nitrogen complex to give the isoindolinone derivatives 8 in good yields.