120238-17-7

Upstream product

• 24393-44-0 2-cyano-3-(3-methoxyphenyl)acrylic acid ethyl ester 
• 544-92-3 copper(I) cyanide 
• 591-31-1 3-methoxy-benzaldehyde 
• 7677-24-9 trimethylsilyl cyanide 
• 3179-09-7 1-methoxy-3-(2-nitrovinyl)benzene 

Downstream Products

• 120238-22-4 4-ethoxalyl-3-(3-methoxyphenyl)-1-(methyl)pyrrolidine-2,5-dione 
• 120238-27-9 1,4-dimethyl-3-(3-methoxyphenyl)-3-pyrroline-2,5-dione 
• 38913-02-9 3-(3-methoxyphenyl)-1-(methyl)pyrrolidine-2,5-dione 
• 120238-18-8 3-(3-methoxyphenyl)pyrrolidine-2,5-dione 

Relevant academic research and scientific papers

Straightforward synthesis of 1,2-dicyanoalkanes from nitroalkenes and silyl cyanide mediated by tetrabutylammonium fluoride

A straightforward synthesis of 1,2-dicyanoalkanes by reacting nitroalkenes with trimethylsilyl cyanide in the presence of tetrabutylammonium fluoride is described. The reaction proceeds through a tandem double Michael addition under mild conditions. Employing the hypervalent silicate generated from trimethylsilyl cyanide and tetrabutylammonium fluoride is essential for achieving this transformation. Mechanistic studies suggest that a small amount of water included in the reaction media plays a key role. This protocol is applicable to various types of substrates including electron-rich and electron-deficient aromatic nitroalkenes, and aliphatic nitroalkenes. Moreover, vinyl sulfones were found to be good alternatives, particularly for electron-deficient nitroalkenes. The broad substrate scope and functional group tolerance of the reaction makes this approach a practical method for the synthesis of valuable 1,2-dicyanoalkanes.

Synthesis of cis-4-methyl-3-phenylpyrrolidines as potential dopaminergic agonists

cis-3-(3,4-Dihydroxyphenyl)-4-methyl-l-(n-propyl)pyrrolidine (23) was synthesized and evaluated for dopaminergic activity. The synthesis of 23 involved selective 4-acylation of the 3-phenylpyrrolidine-2,5-dione 15 and cis-addition of hydrogen to a 4-methy