120239-03-4Relevant academic research and scientific papers
A facile synthesis of highly fluorescent pyrido[2,3-d]pyrimidines and 1,8-naphthyridines via oxazine transformation and enaminic addition reactions
El-Sayed, Hassan A.,Morsy, Hesham A.
, p. 723 - 732 (2019)
Abstract: The synthesis and fluorescence properties of highly substituted bicyclic pryridine derivatives are described. 2-Substituted-4-oxo-pyrido[2,3-d]pyrimidines 2–8 resulted from the acylation reaction of α-aminonicotinonitrile 1 with aroyl chlorides,
Microwave assisted one-pot synthesis of 2-amino-4hchromenes and spiropyrano[2,3-d]pyrimidine
Mahmoud, Alaa F.,Abd El-Latif, Fathy F.,Ahmed, Amira M.
experimental part, p. 91 - 96 (2010/10/02)
A convenient and efficient method using microwave assisted one pot synthesis reactions for synthesis of 4H-benzo[f]chromenes by the reaction of aromatic aldehydes with a mixture of malononitrile and naphthols was examined. The synthesis of spiropyrano[2,3-d]pyrimidines by the reaction of isatin with malononitrile and barbituric acid and/or thiobarbituric acid was investigated. The versatility of the method was also examined through the reaction of aromatic aldehydes and malononitrile with various reagents.
Synthesis and reactions of some pyridopyrimidine and thienopyridine derivatives for antiviral evaluation
Yousif,Morsy,Sayed
experimental part, p. 651 - 660 (2010/10/18)
COMPOUNDS 6-amino-4-(4-chlorophenyl)-2-thien-2-ylpyridine5-carbonitrile (2) and 4-(4-chlorophenyl)-6-thioxo-2-thien-2-yll,6-dihydropyridine-5-carbonitrile (9) were prepaied using 3-(4-chlorophenyl)-l-thien-2-ylpropenone (I) and malononitrile or cyanothioacetamide, respectively. Pyridine derivative 2 was in turn used as a precursor for preparation of some pyridopyrimidine and fused pyridopyrimidine derivatives 3-8. On the other hand, the pyridine derivative 9 was used in preparation of thienopyridine derivatives 10 and 11. Moreover, fusion of compound 11 with excess of benzoyl chloride ' afforded 4-(4-chlorophenyl)-2-phenyl-7-thien-2-yl-3H-pyrido [3′,2′:4,5] thieno[3,2-d] pyrimidin-4-one (12).
