1202396-10-8

Basic information

• Product Name: C₂₆H₂₆ClNO₅
• CAS NO: 1202396-10-8
• Molecular Weight: 467.949
• Mol File: 1202396-10-8.mol

Chemical Properties

• CAS DataBase Reference: C₂₆H₂₆ClNO₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₆H₂₆ClNO₅(1202396-10-8)
• EPA Substance Registry System: C₂₆H₂₆ClNO₅(1202396-10-8)

Safety Data

• Hazardous Substances Data: 1202396-10-8(Hazardous Substances Data)

Upstream product

• 1057404-10-0 N-[(7S)-2,3,10-trimethoxy-9-oxo-1-((phenyl(3-chloro))methoxy)-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide 

Downstream Products

• 1202396-29-9 C₃₀H₂₈ClF₃N₂O₇ 

Relevant articles and documents

NOVEL COLCHICINE DERIVATIVES, METHODS AND USES THEREOF

The invention relates to colchicine derivatives, methods and uses thereof for treatment of cancer. In certain embodiments, the colchicine derivative comprises a compound of formula (I), wherein Z is O or S; R1 is selected fro H, a halo group, a substituted or unsubstituted hydrocarbon group, or a substituted or unsubstituted heterogeneous group; R2 and R3 are each independently selected from H, a halo group, a substituted or unsubstituted hydrocarbon group, a substituted or unsubstituted heterogeneous group, a substituted or unsubstituted carbocyclic group, a substituted or unsubstituted heterocyclic group, substituted or unsubstituted aromatic, or a substituted or unsubstituted heteroaromatic; R is selected from H or a substituted or unsubstituted hydrocarbon group, with the proviso that when R, R2 and R3 are methyl groups, R1 is not -COCH3.

The efficacy of new colchicine derivatives and viability of the T-Lymphoblastoid cells in three-dimensional culture using 19F MRI and HPLC-UV ex vivo

The paper describes ex vivo applications of colchicine derivatives for the treatment of human T-Lymphoblastoid (CEM) cells. Moreover, the role of the substitutions of ring A at C-1 and C-7 side chain of colchicine analogues was probed by the synthesis and examination of their effects on the three-dimensional (3-D) CEM cells' growth. The CEM cells were cultured in the hollow fiber bioreactor (HFB) device. We used 1H and 19F magnetic resonance imaging (MRI) to monitor changes in 3-D CEM cell culture. 19F MRI was used for visualization of the cellular uptake of new fluorine derivatives. Before and after treatment CEM cells profile was investigated with high performance liquid chromatography (HPLC-UV). Crown Copyright