120255-00-7

Basic information

• Product Name: 7-methoxy-5,6-diphenyl-1-benzofuran-4-ol
• Synonyms: 4-benzofuranol, 7-methoxy-5,6-diphenyl-
• CAS NO: 120255-00-7
• Molecular Formula: C₂₁H₁₆O₃
• Molecular Weight: 316.3499
• Mol File: 120255-00-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 328.9°C at 760 mmHg
• Flash Point: 152.7°C
• Density: 1.219g/cm³
• Vapor Pressure: 9.59E-05mmHg at 25°C
• Refractive Index: 1.646
• CAS DataBase Reference: 7-methoxy-5,6-diphenyl-1-benzofuran-4-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 7-methoxy-5,6-diphenyl-1-benzofuran-4-ol(120255-00-7)
• EPA Substance Registry System: 7-methoxy-5,6-diphenyl-1-benzofuran-4-ol(120255-00-7)

Safety Data

• Hazardous Substances Data: 120255-00-7(Hazardous Substances Data)

Upstream product

• 501-65-5 diphenyl acetylene 

Relevant articles and documents

1,4-Dihydronaphthoquinones, hydroindoloquinones, benzofurans, and benzothiophenes as inhibitors of 5-lipoxygenase. Synthesis and structure-activity studies

A series of substituted 1,4-dihydronaphthoquinones, hydroindoloquinones, benzofuran-4,7-dihydroquinones, and benzothiophene-4,7-dihydroquinones were synthesized and evaluated for inhibitory activity against 5-lipoxygenase. These compounds were found to be active in vitro for LTC4/D4 inhibition with the potencies (IC50's) ranging from 0.2 to 85 μM. Active 1,4-dihydronaphthoquinone acetates (IC50 4 inhibition assay. The acetates of 1,4-dihydronaphthoquinones containing the alkyl substituent(s) (2-n-butyl, 11, and 2,3-diethyl, 15) exhibited the best activity in LTC4/D4 inhibition (IC50 = 0.2-0.4 μM, in vitro) as well as in LTB4 inhibition (60-75% inhibition).