1202569-76-3Relevant articles and documents
Total synthesis of (+)-aspicilin from D-mannitol
Yadav,Rao, T. Srinivasa,Ravindar,Reddy, B. V. Subba
, p. 2828 - 2830 (2009)
The total synthesis of the 18-membered lichen macrolide, (+)-aspicilin, has been accomplished utilizing the Swern oxidation, Masamune-Roush olefination, and ring-closing metathesis of a trienic ester as key steps. d-Mannitol has been utilized as the chiral pool material for the construction of the olefinic aldehyde and the Jacobsen hydrolytic kinetic resolution has been employed for the construction of the olefinic phosphonate ester.