1202619-75-7Relevant academic research and scientific papers
Acyclic ketene aminal phosphates derived from N,N-diprotected acetamides: stability and cross-couplings
Simas, Alessandro B.C.,de Sales, Daniel L.,Pais, Karla C.
, p. 6977 - 6980 (2009)
The synthesis of a stable ketene aminal phosphate (α-phosphoryloxy enecarbamate) derived from N,N-diprotected acetamide, bearing two different removable protecting groups, is disclosed. This synthetic intermediate underwent successful palladium-catalyzed cross-coupling reactions to afford functionalized enynes and dienes.
Acyclic ene-carbamate. A useful tool for an original synthesis of phosphine-containing α-amino acids bearing a quaternary carbon
Bouet, Alexis,Cieslikiewicz, Monika,Lewinski, Krzysztof,Coudert, Gérard,Gillaizeau, Isabelle
experimental part, p. 498 - 503 (2010/03/03)
A novel and efficient approach for the synthesis of phosphine-containing α-amino acids bearing quaternary carbon is described. The key step involves the original nucleophilic addition of lithiated phosphines onto acyclic ene-carbamates concomitant with a spontaneous internal (N→C) alkyloxycarbonyl migration.
