1202639-31-3Relevant articles and documents
Substituted pyrimidin-4-one derivatives
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A pyrimidone derivative represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof: Y represents two hydrogen atoms, a sulphur atom, an oxygen atom, an hydroxy group and a hydrogen atom, an hydroxy group and a C1-2 alkyl group, an hydroxy group and a C1-2 perhalogenated alkyl group; a halogen atom and a hydrogen atom or a -(CH2)p-;Z represents a bond, an oxygen atom, NH, a nitrogen atom substituted by a hydrogen atom or a C1-3 alkyl group, a sulphur atom, a methylene group optionally substituted ; R1 represents a 2, 3 or 4-pyridine ring or a 2, 4 or 5-pyrimidine ring, the ring being optionally substituted; R2 represents a hydrogen atom, a C1-6 alkyl group or a halogen atom; R3 represents a hydrogen atom; a phenyl or a naphthyl group, these groups being optionally substituted a 4-15 membered heterocyclic group optionally substituted a -C(O)O (C1-6-alkyl) group optionally substituted ; a -C(O)-phenyl group, a -C(O)O-phenyl group, or a - C(O)O-CH2-phenyl group,the benzene rings of the above-mentioned groups being optionally substituted ; a -C(O)-4-15 membered heterocyclic group optionally substituted; R4 represents a hydrogen atom, a halogen atom, a hydroxyl group, a C1-6 alkyl group optionally substituted; n represents 0 to 3; m represents 0 to 3 ; p represents 2 to 7; in the form of a free base or of an addition salt with an acid. Use in therapeutic
