1202645-50-8

Basic information

• Product Name: 9-MethoxyMethyl Guanine
• Synonyms: 9-MethoxyMethyl Guanine;2-amino-9-(methoxymethyl)-3H-purin-6-one
• CAS NO: 1202645-50-8
• Molecular Formula: C7H9N5O2
• Molecular Weight: 195.17866
• Product Categories: Amines, Aromatics, Nucleotides, Bases & Related Reagents
• Mol File: 1202645-50-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 491.5±51.0 °C(Predicted)
• Appearance: /
• Density: 1.72±0.1 g/cm3(Predicted)
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: Aqueous Base (Slightly), DMSO (Slightly), Methanol (Slightly, Heated)
• PKA: 3.21±0.20(Predicted)
• CAS DataBase Reference: 9-MethoxyMethyl Guanine(CAS DataBase Reference)
• NIST Chemistry Reference: 9-MethoxyMethyl Guanine(1202645-50-8)
• EPA Substance Registry System: 9-MethoxyMethyl Guanine(1202645-50-8)

Safety Data

• Hazardous Substances Data: 1202645-50-8(Hazardous Substances Data)

Usage

Uses

9-MethoxyMethyl Guanine is a derivative of guanine which is on one of the five nucleobases incorporated into biological nucleic acids. Guanine, along with adenine and cytosine, is present in both DNA and RNA, whereas thymine is usually seen only in DNA, and uracil only in RNA. It is used as an analyte in RP-LC for diastereometric drugs.

Upstream product

• 19916-73-5 2-Amino-6-benzyloxypurine 
• 1429306-16-0 C₁₄H₁₅N₅O₂ 

Relevant articles and documents

Synthesis of valganciclovir hydrochloride congeners

Valganciclovir hydrochloride (1) is used for the treatment of cytomegalovirus (CMV) retinitis in patients with weakened immune systems. Valganciclovir hydrochloride is a hydrochloride salt of L-valyl ester of ganciclovir (2) that exists as a mixture of two diastereomers. According to the U.S. Food and Drug Administration specifications, the diastereomeric ratio of valganciclovir hydrochloride 1 should be maintained in the range 55:45 to 45:55. According to the U.S. Food and Drug Administration specifications, the diastereomeric ratio of valganciclovir hydrochloride 1 should be maintained in the range 55:45 to 45:55. During the process development of valganciclovir hydrochloride, six related substances (impurities) were observed along with the final active pharmaceutical ingredient. Among these six impurities, ganciclovir (2) and guanine (3) are the key starting materials and degraded impurities of ganciclovir, respectively. The remaining four impurities were identified as isovalganciclovir hydrochloride (4), methoxymethylguanine (5), O-acetoxy ganciclovir (6), and isovalarylganciclovir (7). The present work describes the synthesis and characterization of these four impurities.