1202651-75-9

Upstream product

• 186581-53-3 diazomethane 
• 156900-02-6 3-benzoyl-1-((6aR,8R,9aS)-2,2,4,4-tetraisopropyl-9-methylenetetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)pyrimidine-2,4(1H,3H)-dione 

Downstream Products

• 1202487-84-0 C₃₇H₄₄N₂O₆Si 
• 1202488-04-7 (4R,6R,7S)-(4-(2-oxo-4-([1,2,4]triazol-1-yl)-pyrimidin-1(2H)-yl)-6-[(4-methoxyphenyl)(diphenyl)methoxymethyl]-5-oxaspiro[2.4]hept-7-yl) isobutyrate 
• 1202487-57-7 (2S)-benzyl 2-((((4R,6R,7S)-4-amino-2-oxopyrimidin-1(2H)-yl)-7-hydroxy-5-oxaspiro[2,4]heptan-6-yl)methoxy)((phenoxy)phosphorylamino)propanoate 
• 1202488-07-0 (4R,6R,7S)-(4-(4-amino-2-oxopyrimidin-1(2H)-yl)-6-[(4-methoxyphenyl)(diphenyl)methoxymethyl]-5-oxaspiro[2.4]-hept-7-yl) isobutyrate 
• 1202488-01-4 (4R,6R,7S)-(4-(2,4-dioxopyrimidin-1(2H)-yl)-6-[(4-methoxyphenyldiphenyl)methoxymethyl]-5-oxaspiro[2.4]-hept-7-yl) isobutyrate 
• 1202487-81-7 1-((4R,6R,7S)-7-hydroxy-6-((4-methoxyphenyl)(diphenyl)methoxymethyl)-5-oxaspiro[2.4]hept-4-yl)-1H-pyrimidin-2,4(1H,3H)-dione 

Relevant academic research and scientific papers

2′-deoxy-2′-spirocyclopropylcytidine revisited: A new and selective inhibitor of the hepatitis C virus NS5B polymerase

The current therapy for hepatitis C virus (HCV) infection has limited efficacy, in particular against the genotype 1 virus, and a range of side effects. In this context of high unmet medical need, more efficacious drugs targeting HCV nonstructural protein