1202942-29-7

Basic information

• Product Name: [1-(4-fluorophenyl)-1H-pyrazol-3-yl]methanol
• Synonyms: [1-(4-fluorophenyl)-1H-pyrazol-3-yl]methanol
• CAS NO: 1202942-29-7
• Molecular Weight: 192.193
• Mol File: 1202942-29-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [1-(4-fluorophenyl)-1H-pyrazol-3-yl]methanol(CAS DataBase Reference)
• NIST Chemistry Reference: [1-(4-fluorophenyl)-1H-pyrazol-3-yl]methanol(1202942-29-7)
• EPA Substance Registry System: [1-(4-fluorophenyl)-1H-pyrazol-3-yl]methanol(1202942-29-7)

Safety Data

• Hazardous Substances Data: 1202942-29-7(Hazardous Substances Data)

Usage

General Description

[1-(4-fluorophenyl)-1H-pyrazol-3-yl]methanol is a chemical compound that belongs to the pyrazole class of compounds. It contains a fluorophenyl group and a hydroxymethyl group attached to a pyrazole ring. [1-(4-fluorophenyl)-1H-pyrazol-3-yl]methanol may have potential applications in the field of medicinal chemistry, as pyrazole-containing compounds have been studied for their pharmacological properties, including anti-inflammatory, analgesic, and antipyretic effects. The fluorophenyl group may also confer specific chemical and biological properties to the compound. Additionally, the presence of the hydroxymethyl group suggests that this compound may have reactivity and potential for further chemical modifications to explore its biological activities. Further research and evaluation of this compound's properties and potential applications in various fields would be necessary to fully understand its potential significance.

Upstream product

• 115342-25-1 ethyl 1–(4-fluorophenyl)-1H-pyrazole-3-carboxylate 

Downstream Products

• 1202942-32-2 3-(bromomethyl)-1-(4-fluorophenyl)-1H-pyrazole 

Relevant articles and documents

Synthesis and structure-activity relationships of antitubercular 2-nitroimidazooxazines bearing heterocyclic side chains

Recently described biphenyl analogues of the antituberculosis drug PA-824 displayed improved potencies against M. tuberculosis but were poorly soluble. Heterobiaryl analogues of these, in which the first phenyl ring was replaced with various 5-membered ring heterocycles, were prepared with the aim of identifying potent new candidates with improved aqueous solubility. The compounds were constructed by coupling the chiral 2-nitroimidazooxazine alcohol with various halomethyl-substituted arylheterocycles, by cycloadditions to a propargyl ether derivative of this alcohol, or by Suzuki couplings on haloheterocyclic methyl ether derivatives. The arylheterocyclic compounds were all more hydrophilic than their corresponding biphenyl analogues, and several showed solubility improvements. 1-Methylpyrazole, 1,3-linked-pyrazole, 2,4-linked-triazole, and tetrazole analogues had 3- to 7-fold higher MIC potencies against replicating M. tb than predicted by their lipophilicities. Two pyrazole analogues were >10-fold more efficacious than the parent drug in a mouse model of acute M. tb infection, and one displayed a 2-fold higher solubility. 2009 American Chemical Society.