120298-37-5Relevant articles and documents
Process for the preparation of 6-substituted-4-oxo-thieno [2,3b]thiopyran-2-sulfonic acid
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Page/Page column 6, (2008/12/04)
The present invention relates to one-pot process for the preparation of 6-substituted-4-oxo-thieno[2,3b]thiopyran-2-sulfonic acid of formula (I), which comprises, reacting 2-thienylthiol with alkenyl acid in the presence of an aromatic hydrocarbon solvent and a base, cyclization of the resulting compound and further reacting with an acid anhydride and sulfuric acid to get the desired compound of formula (I). The compound of formula (I) is the key intermediate in the preparation of (S,S)-5,6-dihydro-4-alkyylamino-6-substituted-4H-thieno[2,3-b]thiopyran-2-sulfonamide-7,7-dioxide and analogs thereof.
Process for preparing 5,6-dihydro-4-(S)-(ethylamino)-6-(S) methyl-4H-thieno[2,3b]thiopyran-2-sulphonamide-7,7-dioxide HCI
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Page/Page column 9, (2008/06/13)
The present invention relates to an improved process for the preparation of 5,6-dihydro-4-(S)-(ethylamino)-6-(S)methyl-4H-thieno[2,3b]thiopyran-2-sulphonamide-7,7-dioxide hydrochloride of formula (I) commonly known as Dorzolamide Hydrochloride useful as an agent to reduce intraoccular pressure by inhibiting carbonic anhydrase enzyme
Substituted aromatic sulfonamides as antiglaucoma agents, compositions and use
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, (2008/06/13)
Aromatic sulfonamides with a saturated heterocycle fused thereto are carbonic anhydrase inhibitors useful in the treatment of elevated intraocular pressure.