1203-25-4Relevant articles and documents
Doxofylline impurity and preparation method thereof
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Paragraph 0020; 0025-0027, (2019/05/22)
The invention provides a doxofylline impurity and a preparation method thereof. The impurity is 9-(2,2-dimethoxyethyl)-1,3-dimethyl-1H-purine-2,6(3H,9H)-diketone. A compound provided by the inventioncan be used as a standard substance for detecting ingredients of a doxofylline finished product, thereby improving the accurate positioning and characterization of the detection and analysis of doxofylline finished product for the impurities, strengthening the control of the impurities, and further improving the quality of the doxofylline finished products.
Divergent synthesis of novel 9-deazaxanthine derivatives via late-stage cross-coupling reactions
Bartoccini, Francesca,Piersanti, Giovanni,Mor, Marco,Tarzia, Giorgio,Minetti, Patrizia,Cabri, Walter
, p. 8860 - 8867 (2013/01/15)
A small library of 8-substituted 9-deazaxanthines has been prepared by late-stage diversification of an 8-bromo-9-deazaxanthine. By utilizing palladium-catalyzed cross-coupling reactions a single key precursor can be transformed into a variety of 8-substituted-9-deazaxanthine compounds. Three key 8-bromo-9-deazaxanthine intermediates were efficiently prepared from commercially available 6-chlorouracil in six steps.
Synthesis and anti-HIV activity of new 6-thioarylpyrimidines and related compounds
Al-Masoudi, Iman A.,Al-Soud, Yaseen A.,Al-Masoudi, Najim A.,Noori, Saman H.,Schuppler, Thilo
scheme or table, p. 1571 - 1583 (2009/06/18)
A series of new 5-nitro- and 5-amino-6-arylsulfanyl-1-propyl-1H-pyrimidin- 2,4-diones (4-9) were synthesized with the aim to develop new non-nucleoside reverse transcriptase inhibitors (NNRTIs). Similarly, 6-arylsulfanyl-1,3- dimethyl-5-nitro-1H-pyrimidin-2,4-diones (12-15) were prepared from 10. A new 2-amino-2-phenyl-7-phenylsulfanyl-imidazo[1,2-a]pyrimidin-5-one (18) has been synthesized from reaction of 17 with α-bromoacetophenone in the presence of NaH. The newly synthesized compounds were evaluated for their anti HIV-1 and HIV-2 activity in MT-4 cells. Copyright Taylor & Francis Group, LLC.