1203-25-4

Usage

Uses

Used in Pharmaceutical Industry:
6-chloro-1,3-dimethyl-5-nitropyrimidine-2,4(1H,3H)-dione serves as an intermediate or active pharmaceutical ingredient in the development of medications targeting various diseases and conditions. Its unique structure allows for specific interactions with biological targets, making it a valuable compound in drug discovery and medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 6-chloro-1,3-dimethyl-5-nitropyrimidine-2,4(1H,3H)-dione is utilized as a component in the formulation of pesticides, herbicides, or other crop protection agents. Its chemical properties enable it to effectively manage pests and enhance crop yields.
Used in Material Science:
6-chloro-1,3-dimethyl-5-nitropyrimidine-2,4(1H,3H)-dione contributes to the advancement of new materials in material science. Its incorporation into polymers or other materials can lead to the development of novel properties, such as improved stability, enhanced reactivity, or specific binding capabilities, which can be applied in various industries.

Upstream product

• 6972-27-6 1,3-Dimethyl-6-chlorouracil 
• 769-42-6 1,3-dimethylbarbituric acid 

Downstream Products

• 90994-73-3 6-(4-Chloro-benzylamino)-1,3-dimethyl-5-nitro-1H-pyrimidine-2,4-dione 
• 82000-36-0 6-Benzylsulfanyl-1,3-dimethyl-5-nitro-1H-pyrimidine-2,4-dione 
• 90994-75-5 6-(Benzyl-methyl-amino)-1,3-dimethyl-5-nitro-1H-pyrimidine-2,4-dione 
• 82000-38-2 4,6-Dimethyl-2-(4-nitrophenyl)thiazolo<5,4-d>pyrimidine-5,7-(4H,6H)dione 1-oxide 
• 90994-74-4 1,3-Dimethyl-5-nitro-6-(1-phenyl-ethylamino)-1H-pyrimidine-2,4-dione 
• 60228-90-2 6-benzylamino-1,3-dimethyl-5-nitro-1H-pyrimidine-2,4-dione 
• 90994-71-1 1,3-Dimethyl-6-(4-methyl-benzylamino)-5-nitro-1H-pyrimidine-2,4-dione 
• 1128-14-9 5-amino-6-chloro-1,3-dimethyluracil 
• 1412914-31-8 1,3,5-trimethyl-6-(phenylethynyl)-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione 
• 519-32-4 isocaffeine 
• 54660-53-6 5-benzyl-1,3-dimethyl-1,5-dihydro-pyrimido[4,5-b][1,4]thiazine-2,4,6-trione 
• 5440-00-6 4,5-Diamino-1,3-dimethyluracil 
• 82000-47-3 4,6-Dimethyl-2-(1'-methylbenzylidenehydrazino)thiazolo<5,4-d>pyrimidine-5,7-(4H,6H)dione 
• 82000-40-6 4,6-Dimethyl-2-(4-nitro-phenyl)-4H-thiazolo[5,4-d]pyrimidine-5,7-dione 

Relevant academic research and scientific papers

Doxofylline impurity and preparation method thereof

The invention provides a doxofylline impurity and a preparation method thereof. The impurity is 9-(2,2-dimethoxyethyl)-1,3-dimethyl-1H-purine-2,6(3H,9H)-diketone. A compound provided by the inventioncan be used as a standard substance for detecting ingredients of a doxofylline finished product, thereby improving the accurate positioning and characterization of the detection and analysis of doxofylline finished product for the impurities, strengthening the control of the impurities, and further improving the quality of the doxofylline finished products.

ETHYNYLXANTHINES, PREPARATION AND USE AS CALCIUM ION CHANNEL MODULATORS

The present invention relates to novel pharmaceutical compounds, which exhibit ability to act as calcium ion channel modulators, methods for their synthesis and the treatment and/or prevention of various diseases and disorders including deregulated calcium ion channel activity.

Divergent synthesis of novel 9-deazaxanthine derivatives via late-stage cross-coupling reactions

A small library of 8-substituted 9-deazaxanthines has been prepared by late-stage diversification of an 8-bromo-9-deazaxanthine. By utilizing palladium-catalyzed cross-coupling reactions a single key precursor can be transformed into a variety of 8-substituted-9-deazaxanthine compounds. Three key 8-bromo-9-deazaxanthine intermediates were efficiently prepared from commercially available 6-chlorouracil in six steps.

AMIDES OF HETEROCYCLIC COMPOUNDS AS TRPA1 INHIBITORS

Amides of heterocyclic compounds as Transient Receptor Potential subfamily A (TRPA) modulators are provided In particular, compounds described herein are useful for treating or preventing diseases, conditions and/ or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1) Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1. (I).

Synthesis and anti-HIV activity of new 6-thioarylpyrimidines and related compounds

A series of new 5-nitro- and 5-amino-6-arylsulfanyl-1-propyl-1H-pyrimidin- 2,4-diones (4-9) were synthesized with the aim to develop new non-nucleoside reverse transcriptase inhibitors (NNRTIs). Similarly, 6-arylsulfanyl-1,3- dimethyl-5-nitro-1H-pyrimidin-2,4-diones (12-15) were prepared from 10. A new 2-amino-2-phenyl-7-phenylsulfanyl-imidazo[1,2-a]pyrimidin-5-one (18) has been synthesized from reaction of 17 with α-bromoacetophenone in the presence of NaH. The newly synthesized compounds were evaluated for their anti HIV-1 and HIV-2 activity in MT-4 cells. Copyright Taylor & Francis Group, LLC.

PURINES AND PYRIMIDINES AND CONDENSED SYSTEMS BASED ON THEM. 2. SYNTHESIS OF 1-METHYL-9-AMINOXANTHINE AND 9-AMINOTHEOPHYLLINE

The previously unknown 9-aminotheophylline and 1-methyl-9-aminoxanthine were synthesized from 3-methyl-5-amino-6-hydrazinouracil.In the case of 1-methyl-9-aminoxanthine an x-ray diffraction study of an N-amino derivative of an NH heterocycle was made for the first time.