1203-40-3Relevant academic research and scientific papers
Preparation method of chenodeoxycholic acid
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Paragraph 0166; 0168-0169, (2021/01/24)
The invention relates to the technical field of medicine synthesis, in particular to a preparation method of chenodeoxycholic acid. The invention develops a method for synthesizing the chenodeoxycholic acid by taking hyodeoxycholic acid(3alpha, 6alpha-dihydroxy-5beta-cholanic acid)as a raw material through nine steps of reaction, the reaction conditions of each step are mild, the control is easy,the process is simple, the used raw materials are wide in source, low in price and easy to obtain, the yield is high, the total yield can reach 61%, the synthesis cost is low, and the method is suitable for mass preparation and industrial production.
Process for steroid preparation
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, (2008/06/13)
A process for the preparation of a compound of the formula STR1 wherein R1 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms optionally substituted by halogen or a nitrogen or oxygen function and alkenyl and alkynyl of 2 to 4 carbon atoms, R2 is alkyl of 1 to 4 carbon atoms and the A, B, C and D rings are optionally substituted by at least one member of the group consisting of optionally protected --OH or =0, halogen, alkyl and alkoxy of 1 to 4 carbon atoms and alkenyl and alkynyl of 2 to 4 carbon atoms comprising reacting a compound of the formula STR2 wherein R1 and R2 and the A, B, C and D rings are defined as above with an oxidizing agent in the presence of water and an at least partially water-miscible solvent to obtain a compound of the formula STR3 wherein R1 and R2 and the A, B, C and D rings are defined as above, subjecting the latter to a solvolysis in a basic or acidic media and optionally subjecting the product to a deprotection reaction of any protected --OH or =0 groups to obtain the compound of formula I and novel intermediates.
Process for the production of aromatic peroxycarboxylic acids
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, (2008/06/13)
Aromatic peroxycarboxylic acids are produced by reacting aromatic carboxylic acids with hydrogen peroxide in the presence of sulfuric acid by having a mixture of aqueous 50-99 weight % H2 O2 and sulfuric acid present in the reaction vessel, introducing the solid aromatic carboxylic acid with stirring, the reaction being carried out in heterogeneous phase, the stirring being continued to the end of the reaction and then the reaction mixture obtained worked up in known manner.
7-Oxa steroids
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, (2008/06/13)
7-Oxa steroids which may be substituted in the 3-position with a hydroxy or oxo group or in the 2-position with a hydroxymethylene group or in the 2- and 3-positions with a substituent that forms a 5-membered heterocyclic ring, useful as antigonadotropic agents and a method of preparing these 7-oxa steroids from 3-hydroxy Δ5 -steroids including intermediates in this process.
