120301-10-2

Upstream product

• 349-95-1 4-(trifluoromethyl)benzylic alcohol 
• 103-84-4 Acetanilid 
• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 79478-02-7 4-(trifluoromethyl)phenylglyoxylic acid 

Downstream Products

• 120301-13-5 2-chloro-4-(4-trifluoromethylphenyl)quinoline 
• 105189-13-7 2-(4-Ethyl-piperazin-1-yl)-4-(4-trifluoromethyl-phenyl)-quinoline 
• 105189-15-9 2-[4-(2-hydroxyethyl)-1-piperazinyl]-4-(4-trifluoromethylphenyl)quinoline 
• 682812-78-8 {Benzotriazol-1-yl-[2-(4-trifluoromethyl-benzoyl)-phenylcarbamoyl]-methyl}-carbamic Acid Benzyl Ester 
• 682812-79-9 [2-oxo-5-(4-trifluoromethylphenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]carbamic acid benzyl ester 
• 790-10-3 (2-Amino-phenyl)-(4-trifluoromethyl-phenyl)-methanone 
• 120301-11-3 4-(4-trifluoromethylphenyl)-2-quinolinone 

Relevant academic research and scientific papers

Palladium-catalyzed C-H bond acylation of acetanilides with benzylic alcohols under aqueous conditions

Palladium-catalyzed dehydrogenative coupling reactions between acetanilides and benzylic alcohols under aqueous conditions are reported. A wide range of benzophenone derivatives could be obtained in good to excellent yields up to 98 %. Mechanism studies showed that a bimetallic palladium cyclopalladated complex might be involved in the catalysis.

Merging Photoredox with Palladium Catalysis: Decarboxylative ortho-Acylation of Acetanilides with α-Oxocarboxylic Acids under Mild Reaction Conditions

A room temperature decarboxylative ortho-acylation of acetanilides with α-oxocarboxylic acids has been developed via a novel Eosin Y with Pd dual catalytic system. This dual catalytic reaction shows a broad substrate scope and good functional group tolera

Palladium-catalyzed oxidative C-H bond acylation of acetanilides with benzylic alcohols

An efficient and clean method to construct C-C bonds has been developed via the acylation reaction of acetanilides with benzylic alcohols using tert-butyl hydroperoxide (TBHP) as oxidant catalyzed by palladium acetate in the presence of triflic acid (TfOH). The acylation reactions exhibit excellent reactivities, and up to 95% yield of the corresponding aryl ketone could be obtained under the optimal conditions. Copyright

Palladium-catalyzed ortho-acylation of acetanilides with aldehydes through direct Ci-H bond activation

Easy access to o-acyl acetanilides: A new Pd-catalyzed ortho-acylation of acetanilides with both aromatic and aliphatic aldehydes has been developed based on a Ci-H activation process. In the presence of tert-butyl hydroperoxide (TBHP) as the ideal oxidant, this reaction provides an efficient access to ortho-acyl acetanilides in good yields (see scheme). Copyright

Room temperature palladium-catalyzed decarboxylative ortho -acylation of acetanilides with α-oxocarboxylic acids

A novel Pd-catalyzed decarboxylative ortho-acylation of acetanilides with α-oxocarboxylic acids is realized at room temperature. This reaction provides efficient access to o-acyl acetanilides under mild conditions.