1203416-45-8

Basic information

• Product Name: N-(3-aminophenyl)cyclopropanesulfonamide
• Synonyms: N-(3-aminophenyl)cyclopropanesulfonamide
• CAS NO: 1203416-45-8
• Molecular Weight: 212.272
• Mol File: 1203416-45-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(3-aminophenyl)cyclopropanesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-aminophenyl)cyclopropanesulfonamide(1203416-45-8)
• EPA Substance Registry System: N-(3-aminophenyl)cyclopropanesulfonamide(1203416-45-8)

Safety Data

• Hazardous Substances Data: 1203416-45-8(Hazardous Substances Data)

Upstream product

• 68621-88-5 (3-aminophenyl)carbamic acid tert-butyl ester 
• 1445792-38-0 tert-butyl (3-(cyclopropanesulfonamido)phenyl)carbamate 
• 99-09-2 3-nitro-aniline 

Downstream Products

• 1445786-34-4 4-((3-(cyclopropanesulfonamido)phenyl)amino)-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-carboxamide 

Relevant articles and documents

BRD4-KINASE INHIBITORS AS CANCER THERAPEUTICS

Disclosed herein are compounds that are inhibitors of BDR4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BDR4 are also disclosed. In certain aspects, disclosed are compounds of Formula I through IV.

CHEMICAL COMPOUNDS

The invention is directed to substituted quinoline derivatives. Specifically, the invention is directed to compounds according to Formula (I): wherein R1, R2, R3; R4; and R5 are defined herein. The compounds of the invention are inhibitors of lactate dehydrogenase A and can be useful in the treatment of cancer and diseases associated with tumor cell metabolism, such as cancer, and more specifically cancers of the breast, colon, prostate and lung. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting lactate dehydrogenase A activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.