120343-45-5Relevant articles and documents
Rhodium(I)-catalysed Asymmetric Hydrogenation of Imines
Kang, Guo-Jun,Cullen, William R.,Fryzuk, Michael D.,James, Brian R.,Kutney, James P.
, p. 1466 - 1467 (1988)
The imines ArC(Me)=NCH2Ph (Ar = Ph, 2-MeO-C6H4, 4-MeO-C6H4) are hydrogenated to the corresponding secondary amines at 1000 psig H2, in 1:1 C6H6/MeOH, using an in situ RhI/(R)-cycphos system (cycphos = Ph2PCH(C6H11)CH2PPh2); a maximum of 91percent enantiomeric excess (e.e.) is achieved at lower temperatures (-25 deg C) in the presence of iodide cocatalyst.