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1203556-18-6

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1203556-18-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1203556-18-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,0,3,5,5 and 6 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1203556-18:
(9*1)+(8*2)+(7*0)+(6*3)+(5*5)+(4*5)+(3*6)+(2*1)+(1*8)=116
116 % 10 = 6
So 1203556-18-6 is a valid CAS Registry Number.

1203556-18-6Relevant articles and documents

PCW-1001, a Novel Pyrazole Derivative, Exerts Antitumor and Radio-Sensitizing Activities in Breast Cancer

Ahn, Jiyeon,Cho, Suk Joon,Jung, Kwan-Young,Kang, Minsung,Kim, Ah-Young,Kim, Jae-Sung,Kwon, Young-Ju,Lee, Kyu Myung,Oh, Jeong Su,Pandit, Navin,Wu, Sangwook

, (2022/04/22)

As pyrazole and its derivatives have a wide range of biological activities, including anticancer activity, the design of novel pyrazole derivatives has emerged as an important research field. This study describes a novel pyrazole derivative that exerts antitumor and radiosensitizing activities in breast cancer both in vitro and in vivo. We synthesized a novel pyrazole compound N,N-dimethyl-N’-(3-(1-(4-(trifluoromethyl)phenyl)-1H-pyrazol-4-yl)phenyl)azanesulfonamide (PCW-1001) and showed that it inhibited several oncogenic properties of breast cancer both in vitro and in vivo. PCW-1001 induced apoptosis in several breast cancer cell lines. Transcriptome analysis of PCW-1001-treated cells showed that it regulates genes involved in the DNA damage response, suggesting its potential use in radiotherapy. Indeed, PCW-1001 enhanced the radiation sensitivity of breast cancer cells by modulating the expression of DNA damage response genes. Therefore, our data describe a novel pyrazole compound, PCW-1001, with antitumor and radiosensitizer activities in breast cancer.

PPAR active compounds

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Page/Page column 121, (2008/12/08)

Compounds are described that are active on at least one of PPARα, PPARδ, and PPARγ, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARα, PPARδ, and PPARγ.

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