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120356-52-7

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120356-52-7 Usage

General Description

2-(2-oxopyrrolidin-1-yl)-N-(2-phenylethyl)acetamide is a chemical compound that is also known by the names N-phenethyl-2-pyrrolidone and 2-PVP. It is a synthetic compound that belongs to the class of pyrrolidone derivatives. This chemical is commonly used as a precursor in the synthesis of various pharmaceuticals and drugs. It has been found to possess hypnotic and sedative properties, making it useful in the treatment of various medical conditions. Additionally, it has been studied for its potential use as a drug delivery system and in the development of new formulations for controlled drug release. Furthermore, it is also used in the production of some personal care products and as a solvent in various industrial processes.

Check Digit Verification of cas no

The CAS Registry Mumber 120356-52-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,0,3,5 and 6 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 120356-52:
(8*1)+(7*2)+(6*0)+(5*3)+(4*5)+(3*6)+(2*5)+(1*2)=87
87 % 10 = 7
So 120356-52-7 is a valid CAS Registry Number.

120356-52-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(2-oxopyrrolidin-1-yl)-N-(2-phenylethyl)acetamide

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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More Details:120356-52-7 SDS

120356-52-7Relevant articles and documents

Synthesis and anticonvulsant activity of some 1-substituted-2- oxopyrrolidine derivatives, II

Al-Obaid, Abdulrahman M.,El-Subbagh, Hussein I.,Al-Shabanah, Othman A.,Elmazar, Mohamed M.

, p. 696 - 721 (2007/10/03)

In the present study, as an attempt to locate new antiepileptic agent(s) with less side effects as well as toxicity, a new series of N-substituted-2- oxopyrrolidine derivatives was synthesized as GABA prodrugs and evaluated for their anticonvulsant activity adopting various screening models. N(4- Fluorobenzyl)-2-(2-oxopyrrolidin-1-yl)acetamide (14) proved to possess a potent broad spectrum anticonvulsant activity with wide safety margin, compared with valproic acid. Compound 14 is more potent (ED50 = 0.43 vs 0.71 mmol/kg for valproate) and has a higher protective index against convulsions (PI = 2.81 vs 1.4-2.36 for valproate). Compound 14 with doses up to 0.5 and 1.0 g/kg, i.p., did not produce mortality within 24 h after administration. N-(4-Methoxybenzyl)-2-(2-oxopyrrolidin-1-yl)acetamide (15), N-(phenylethyl)-2-(2-oxopyrrolidin-1-yl)acetamide (16) and N-[2-(4- fluorophenyl)ethyl]-2-(2-oxopyrrolidin-1-yl)acetamide (17) are also among the potent derivatives found in this investigation. Compounds 14-17, however, have lipophilicity Log (p) values of 0.12-0.68 which is lower than that of valproate. The finding that compounds 14-16 protect against bicuculline- induced convulsions, confirms the rationale behind the design of the present series of compounds as GABA prodrugs.

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