1203652-46-3Relevant academic research and scientific papers
Optimization of pharmacokinetics through manipulation of physicochemical properties in a series of HCV inhibitors
Lazerwith, Scott E.,Bahador, Gina,Canales, Eda,Cheng, Guofeng,Chong, Lee,Clarke, Michael O.,Doerffler, Edward,Eisenberg, Eugene J.,Hayes, Jaclyn,Lu, Bing,Liu, Qi,Matles, Mike,Mertzman, Michael,Mitchell, Michael L.,Morganelli, Philip,Murray, Bernard P.,Robinson, Margaret,Strickley, Robert G.,Tessler, Megan,Tirunagari, Neeraj,Wang, Jianhong,Wang, Yujin,Zhang, Jennifer R.,Zheng, Xubin,Zhong, Weidong,Watkins, William J.
, p. 715 - 719 (2011/12/01)
A novel series of HCV replication inhibitors based on a pyrido[3,2-d]pyrimidine core were optimized for pharmacokinetics (PK) in rats. Several associations between physicochemical properties and PK were identified and exploited to guide the design of comp
