120369-25-7

Basic information

• Product Name: (2S)-2-AMino-N-benzyl-3-MethylbutanaMide
• Synonyms: (2S)-2-AMino-N-benzyl-3-MethylbutanaMide;N-Benzyl L-ValinaMide
• CAS NO: 120369-25-7
• Molecular Formula: C₁₂H₁₈N₂O
• Molecular Weight: 206.28412
• Mol File: 120369-25-7.mol
• Article Data: 31

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2S)-2-AMino-N-benzyl-3-MethylbutanaMide(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-2-AMino-N-benzyl-3-MethylbutanaMide(120369-25-7)
• EPA Substance Registry System: (2S)-2-AMino-N-benzyl-3-MethylbutanaMide(120369-25-7)

Safety Data

• Hazardous Substances Data: 120369-25-7(Hazardous Substances Data)

Upstream product

• 13734-41-3 t-Boc-L-valine 
• 100-46-9 benzylamine 
• 1149-26-4 (S)-N-(benzyloxycarbonyl)valine 
• 241160-62-3 (9H-fluoren-9-yl)methyl(S)-(1-(benzylamino)-3-methyl-1-oxobutan-2-yl)carbamate 
• 103321-53-5 (S)-(9H-fluoren-9-yl)methyl 1-chloro-3-methyl-1-oxobutan-2-ylcarbamate 
• 72-18-4 L-valine 
• 66866-46-4 C₁₅H₂₇NO₆ 
• 1201901-59-8 (S)-2-amino-N-benzyl-3-methylbutyramide hydrochloride 
• 3392-12-9 Boc-Val-ONSu 
• 3496-11-5 2,5-dioxopyrrolidin-1-yl (2S)-2-(((benzyloxy)carbonyl)amino)-3-methylbutanoate 
• 6306-52-1 L-valine methylester hydrochloride 
• 186581-53-3 diazomethane 
• 67106-22-3 tert-butyl (S)-1-(benzylamino)-3-methyl-1-oxobutan-2-ylcarbamate 
• 20998-83-8 (S)-benzyl (1-(benzylamino)-3-methyl-1-oxobutan-2-yl)carbamate 

Downstream Products

• 1056675-55-8 (2S,4S,5S)-5-azido-6-(3-((1RS)-1-(t-butoxycarbonylamino)ethyl)benzyloxy)-4-hydroxy-2-isopropyl-hexanoic acid ((S)-1-benzylcarbamoyl-2-methyl-propyl)-amide 
• 1201901-60-1 (S)-N-benzyl-2-{[1-((S,R)-2-benzyloxymethyloxiranyl)methylidene]amino}-3-methylbutyramide 
• 1258421-36-1 C₂₇H₂₈N₂O 
• 1375257-26-3 (S)-3-acetyl-1-benzyl-4-isopropylimidazolidin-2-one 
• 1375257-34-3 (S)-1-benzyl-3-[(S)-3-hydroxy-3-phenylpropanoyl]-4-isopropylimidazolidin-2-one 
• 1056671-27-2 (2S,4S,5S)-5-amino-6-(3-(1-(t-butoxycarbonylamino)ethyl)benzyloxy)-4-hydroxy-2-isopropyl-hexanoic acid ((S)-1-benzylcarbamoyl-2-methyl-propyl)-amide 
• 161510-47-0 [(S)-1-[(1S,2R,3R)-1-Benzyl-3-benzylamino-3-((S)-1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-2-hydroxy-propylcarbamoyl]-2-(1H-indol-3-yl)-ethyl]-carbamic acid benzyl ester 
• 161389-24-8 (2R,3R,4S)-4-{(S)-2-[3-(1H-Benzoimidazol-2-ylmethyl)-3-methyl-ureido]-3-methyl-butyrylamino}-2-benzylamino-3-hydroxy-5-phenyl-pentanoic acid ((S)-1-benzylcarbamoyl-2-methyl-propyl)-amide 
• 161389-21-5 SDZ 283365 
• 161510-48-1 SDZ 282395 
• 161510-44-7 SDZ 282391 

Relevant articles and documents

Enantioselective Synthesis of Cyclohexenol Derivatives from ?-Aryl-Substituted Enals via an Organocatalyzed Three-Component Reaction

A three-component reaction between ?-aryl-substituted α,β-unsaturated aldehydes and nitroalkenes was realized by using cinchona alkaloid-derived (thio)ureas and squaramides via the dienolate intermediates. This unprecedented 1,3- A nd 1,5-reactivity of dienolates of the ?-aryl-α,β-unsaturated aldehydes led to the formation of cyclohexenol derivatives with four contiguous stereogenic centers and a chiral substituent at C2 with good diastereoselectivities and high ee values. Such reactivities of the dienolates are totally different from those of the corresponding dienamine intermediates.

Protecting-Group-Free Amidation of Amino Acids using Lewis Acid Catalysts

Amidation of unprotected amino acids has been investigated using a variety of ‘classical“ coupling reagents, stoichiometric or catalytic group(IV) metal salts, and boron Lewis acids. The scope of the reaction was explored through the attempted synthesis of amides derived from twenty natural, and several unnatural, amino acids, as well as a wide selection of primary and secondary amines. The study also examines the synthesis of medicinally relevant compounds, and the scalability of this direct amidation approach. Finally, we provide insight into the chemoselectivity observed in these reactions.

l-tert-Leucine-Derived AmidPhos-Silver(I) Chiral Complexes for the Asymmetric [3+2] Cycloaddition of Azomethine Ylides

The l-tert-leucine-derived AmidPhos/silver(I) catalytic system has been developed for the asymmetric [3+2] cycloaddition of azomethine ylides with electronic-deficient alkenes with or without Et3N. Under optimal conditions, highly functionalized endo-4-pyrrolidines were obtained with modest to high yields (up to 99% yield) and enantioselectivities (up to 98% ee).