1203705-55-8 Usage
Uses
Used in Organic Synthesis:
3-bromo-1H-pyrazol-5-amine is utilized as a key intermediate in organic synthesis for the creation of a variety of heterocyclic compounds. Its unique structure allows for the development of complex organic molecules that can be tailored for specific applications.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 3-bromo-1H-pyrazol-5-amine is employed as a building block for the synthesis of bioactive molecules. Its presence in these compounds can contribute to their pharmacological properties, making it a valuable component in drug discovery and development.
Used in Pharmaceutical Industry:
3-bromo-1H-pyrazol-5-amine holds potential applications in the pharmaceutical industry due to its ability to inhibit certain enzymes and its potential antifungal and antileishmanial activities. These characteristics make it a promising candidate for the development of new drugs to combat various diseases and conditions.
Used in Enzyme Inhibition:
3-broMo-1H-pyrazol-5-aMine has been studied for its capacity to inhibit specific enzymes, which can be crucial in the regulation of biological processes and the treatment of enzyme-related disorders. Its role in enzyme inhibition highlights its potential as a therapeutic agent.
Used in Antifungal Applications:
3-bromo-1H-pyrazol-5-amine has demonstrated potential antifungal activities, making it a candidate for use in antifungal medications. This can be particularly beneficial in treating fungal infections and developing resistance strategies against fungi.
Used in Antileishmanial Applications:
3-broMo-1H-pyrazol-5-aMine has also shown promise in antileishmanial studies, indicating its potential use in the development of treatments for Leishmaniasis, a disease caused by protozoan parasites of the genus Leishmania.
Check Digit Verification of cas no
The CAS Registry Mumber 1203705-55-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,0,3,7,0 and 5 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1203705-55:
(9*1)+(8*2)+(7*0)+(6*3)+(5*7)+(4*0)+(3*5)+(2*5)+(1*5)=108
108 % 10 = 8
So 1203705-55-8 is a valid CAS Registry Number.
1203705-55-8Relevant academic research and scientific papers
TETRAHYDROPYRAZOLOPYRIMIDINE COMPOUNDS
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Paragraph 0521, (2014/01/07)
Embodiments of the disclosure relate to tetrahydropyrazolopyrimidine compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis
Novel synthesis and structural characterization of a high-affinity paramagnetic kinase probe for the identification of non-ATP site binders by nuclear magnetic resonance
Moy, Franklin J.,Lee, Arthur,Gavrin, Lori Krim,Xu, Zhang Bao,Sievers, Annette,Kieras, Elizabeth,Stochaj, Wayne,Mosyak, Lidia,McKew, John,Tsao, Désirée H. H.
experimental part, p. 1238 - 1249 (2010/07/18)
To aid in the pursuit of selective kinase inhibitors, we have developed a unique ATP site binder tool for the detection of binders outside the ATP site by nuclear magnetic resonance (NMR).We report here the novel synthesis that led to this paramagnetic spin-labeled pyrazolopyrimidine probe (1), which exhibits nanomolar inhibitory activity against multiple kinases. We demonstrate the application of this probe by performing NMR binding experiments with Lck and Src kinases and utilize it to detect the binding of two compounds proximal to the ATP site. The complex structure of the probe with Lck is also presented, revealing how the probe fits in the ATP site and the specific interactions it has with the protein. We believe that this spinlabeled probe is a valuable tool that holds broad applicability in a screen for non-ATP site binders. 2009 American Chemical Society.
