1203705-58-1

Basic information

• Product Name: 2-BroMo-7-chloropyrazolo[1,5-a]pyriMidine
• Synonyms: 2-BroMo-7-chloropyrazolo[1,5-a]pyriMidine
• CAS NO: 1203705-58-1
• Molecular Formula: C6H3BrClN3
• Molecular Weight: 232.46512
• Mol File: 1203705-58-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 2.03±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.33±0.40(Predicted)
• CAS DataBase Reference: 2-BroMo-7-chloropyrazolo[1,5-a]pyriMidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BroMo-7-chloropyrazolo[1,5-a]pyriMidine(1203705-58-1)
• EPA Substance Registry System: 2-BroMo-7-chloropyrazolo[1,5-a]pyriMidine(1203705-58-1)

Safety Data

• RIDADR: UN2811
• Hazardous Substances Data: 1203705-58-1(Hazardous Substances Data)

Usage

General Description

2-Bromo-7-chloropyrazolo[1,5-a]pyrimidine is a chemical compound with the molecular formula C6H3BrClN2. It is a pyrazolopyrimidine derivative used in the field of medicinal chemistry as a building block for the synthesis of various biologically active compounds. 2-BroMo-7-chloropyrazolo[1,5-a]pyriMidine is often utilized in the development of pharmaceuticals and agrochemicals due to its potential therapeutic and agricultural applications. Additionally, it has been studied for its potential use in the treatment of various diseases and as a pesticide. The unique structure of 2-bromo-7-chloropyrazolo[1,5-a]pyrimidine makes it a valuable tool in the discovery and development of new drugs and chemical products.

Upstream product

• 1203705-57-0 2-bromo-4,7-dihydropyrazolo[1,5-α]pyrimidin-7-one 

Downstream Products

• 1203705-59-2 3-[(2-bromopyrazolo[1,5-α]pyrimidin-7-yl)amino]phenol 

Relevant articles and documents

Novel synthesis and structural characterization of a high-affinity paramagnetic kinase probe for the identification of non-ATP site binders by nuclear magnetic resonance

To aid in the pursuit of selective kinase inhibitors, we have developed a unique ATP site binder tool for the detection of binders outside the ATP site by nuclear magnetic resonance (NMR).We report here the novel synthesis that led to this paramagnetic spin-labeled pyrazolopyrimidine probe (1), which exhibits nanomolar inhibitory activity against multiple kinases. We demonstrate the application of this probe by performing NMR binding experiments with Lck and Src kinases and utilize it to detect the binding of two compounds proximal to the ATP site. The complex structure of the probe with Lck is also presented, revealing how the probe fits in the ATP site and the specific interactions it has with the protein. We believe that this spinlabeled probe is a valuable tool that holds broad applicability in a screen for non-ATP site binders. 2009 American Chemical Society.