120373-24-2

Basic information

• Product Name: Isopropyl unoprostone
• Synonyms: RESCULA;UNOPROSTONE ISOPROPYL ESTER;isopropyl unoprostone;9ALPHA,11ALPHA-DIHYDROXY-15-OXO-20A,20B-DIHOMOPROST-5-EN-1-OIC ACID, ISOPROPYL ESTER;(5z)-7-((1r,2r,3r,5s)-3,5-dihydroxy-2-(3-oxodecyl)cyclopentyl)-5-heptenoic acid 1-methylethyl ester;13,14-dihydro-15-keto-20-ethyl-pgf;13,14-DIHYDRO-15-KETO-20-ETHYL PROSTAGLANDIN F2ALPHA ISOPROPYL ESTER;(5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-(3-oxodecyl)cyclopenthyl]-5-heptenoic Acid Isopropyl Ester
• CAS NO: 120373-24-2
• Molecular Formula: C25H44O5
• Molecular Weight: 424.61
• EINECS: 1312995-182-4
• Product Categories: Prostaglandins;Prostaglandin;Intermediates & Fine Chemicals;Pharmaceuticals;Chiral Reagents
• Mol File: 120373-24-2.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 546.3 °C at 760 mmHg
• Flash Point: 172.2 °C
• Appearance: /
• Density: 1.019 g/cm³
• Vapor Pressure: 3.27E-14mmHg at 25°C
• Refractive Index: 1.491
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• PKA: 14.79±0.70(Predicted)
• CAS DataBase Reference: Isopropyl unoprostone(CAS DataBase Reference)
• NIST Chemistry Reference: Isopropyl unoprostone(120373-24-2)
• EPA Substance Registry System: Isopropyl unoprostone(120373-24-2)

Safety Data

• Hazardous Substances Data: 120373-24-2(Hazardous Substances Data)

Usage

Description

Different sources of media describe the Description of 120373-24-2 differently. You can refer to the following data:
1. Unoprostone isopropyl ester, a novel prostaglandin derivative, was launched in Japan as eye drops for the treatment of glaucoma and ocular hypertension. In animal and human studies, a single drop of unoprostone isopropyl ester induced significant decrease in intraocular pressure without systemic effects, myosis or mydriasis. Unlike prostaglandin analogs such as PGF2α, unoprostone isopropyl ester does not cause irritation in outer segment of the eye or significant changes in aqueous protein concentration and corneal endothelial permeability. Unoprostone isopropyl ester is suggested to act by increasing uveoscleral outflow or by decreasing episcleral venous pressure, resulting in ocular hypotension.
2. Unoprostone isopropyl ester (Rescula) is the clinically approved, prodrug form of unoprostone, which is a free acid analog of prostaglandin F2α (PGF2α). Both latanoprost and Rescula have been approved for the treatment of ocular hypertension. Both analogs of PGF2α are believed to act by increasing the rate of aqueous humor outflow through the uveoscleral pathway. Both drugs are believed to act as prodrugs, with endogenous esterases within the eye releasing the free acid active form of the drug. The typical does of Rescula (one drop of 0.12% solution) is nearly 100 times that of latanoprost. Rescula has very little activity on isolated DP or TP receptors, less than 0.0005% the activity of PGE2 on EP3 receptors, and about 3% of the activity of PGF2α on FP receptors.

Chemical Properties

Clear Colourless Oil

Originator

Ueno (Japan)

Uses

Different sources of media describe the Uses of 120373-24-2 differently. You can refer to the following data:
1. Antiglaucoma; used in treatment of ocular hypertension.
2. Isopropyl unoprostone is an antiglaucoma,it is used in treatment of ocular hypertension.

Definition

ChEBI: A carboxylic ester that is the isopropyl ester of unoprostone.

Brand name

Rescuia

Hazard

A poison.

InChI:InChI=1/C25H44O5/c1-4-5-6-7-10-13-20(26)16-17-22-21(23(27)18-24(22)28)14-11-8-9-12-15-25(29)30-19(2)3/h8,11,19,21-24,27-28H,4-7,9-10,12-18H2,1-3H3/b11-8+/t21-,22-,23+,24-/m1/s1