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• 171349-87-4 N-propyl-N-(4-cyclohexylbenzyl)amine 

Relevant academic research and scientific papers

An exceptionally simple and catalytic method for regeneration of carbonyl functionality from the corresponding 1,3-oxathiolanes

A wide variety of 1,3-oxathiolanes 1 can be chemo-selectively deprotected to the corresponding carbonyl compounds 2 in good yields by employing V2O5-H2O2 catalyzed oxidation of ammonium bromide in a CH2Cl2- H2O mixture at 0-5°C. Some of the major advantages of this procedure are its mild conditions, and that it is highly selective and efficient, high yielding, and cost-effective. Furthermore, no brominations occur at the double bond or allylic position or α to the keto position or aromatic ring.

A useful and catalytic method for protection of carbonyl compounds into the corresponding 1,3-oxathiolanes and deprotection to the parent carbonyl compounds

A wide variety of carbonyl compounds 1 can be easily protected to the corresponding 1,3-oxathiolanes 2 in good yields in the presence of catalytic amount of perchloric acid in dry CH2Cl2 at 0-5 °C. On the other hand, various 1,3-oxathiolanes 2 can be selectively deprotected to the parent carbonyl compounds 1 in very good yields by H2MoO4·H2O-H2O2 catalyzed oxidation of ammonium bromide in the presence of perchloric acid in CH2Cl2-H2O solvent system. Mild reaction condition, high selectivity, efficient and relatively good yields are some of the major advantages of the procedure.

A useful and environmentally benign synthetic protocol for dethiolization by employing vanadium pentoxide catalyzed oxidation of ammonium bromide by hydrogen peroxide

A wide variety of thioacetals and thioketals can be cleaved chemoselectively in presence of olefin and aromatic ring as well as other protecting groups to carbonyl compounds by employing V2O5 catalyzed oxidation of ammonium bromide by H2O2 in CH2Cl2-H2O solvent system; mild conditions, high selectivity, good yield, and no side products such as bromination or oxidation are some of the major advantages.

Inhibitors of squalene synthetase and protein farnesyltransferase

The present invention provides a compound of the formula STR1 which inhibit squalene synthetase and cholesterol biosynthesis and are useful in the treatment of e.g., hyperlipidaemia, atherosclerosis, or fungal infections, processes for the preparation of the compounds of the invention, intermediates useful in these processes, and pharmaceutical compositions containing the compounds.

Inhibitors of protein farnesyltransferase and squalene synthase

The present invention provides a compound of the formula STR1 or a pharmaceutically acceptable salt thereof, which are useful in inhibiting protein farnesyltransferase and the farnesylation of the oncogene protein Ras or inhibiting de novo squalene production resulting in the inhibition of cholesterol biosynthesis, processes for the preparation of the compounds of the invention in addition to intermediates useful in these processes, a pharmaceutical composition, and to methods of using such compounds.