120378-12-3 Usage
General Description
[R,S]-tert-Butyl 3-amino-2-methylpropionate is a chemical compound with the molecular formula C8H17NO2. It is a chiral compound with a chiral center at the carbon atom bearing the amino group. [R,S]-tert-Butyl 3-amino-2-methylpropionate is commonly used as a reagent in organic synthesis, especially in the formation of peptide bonds, and also as a building block in the production of pharmaceuticals and agrochemicals. Its tert-butyl group provides steric hindrance, making it a useful chiral auxiliary in asymmetric synthesis. Additionally, the amino and ester moieties in its structure make it suitable for constructing a variety of bioactive molecules. Overall, [R,S]-tert-Butyl 3-amino-2-methylpropionate is a versatile compound with multiple applications in organic chemistry and drug discovery.
Check Digit Verification of cas no
The CAS Registry Mumber 120378-12-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,0,3,7 and 8 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 120378-12:
(8*1)+(7*2)+(6*0)+(5*3)+(4*7)+(3*8)+(2*1)+(1*2)=93
93 % 10 = 3
So 120378-12-3 is a valid CAS Registry Number.
120378-12-3Relevant articles and documents
Controlling Intramolecular Interactions in the Design of Selective, High-Affinity Ligands for the CREBBP Bromodomain
Brand, Michael,Clayton, James,Moroglu, Mustafa,Schiedel, Matthias,Picaud, Sarah,Bluck, Joseph P.,Skwarska, Anna,Bolland, Hannah,Chan, Anthony K. N.,Laurin, Corentine M. C.,Scorah, Amy R.,See, Larissa,Rooney, Timothy P. C.,Andrews, Katrina H.,Fedorov, Oleg,Perell, Gabriella,Kalra, Prakriti,Vinh, Kayla B.,Cortopassi, Wilian A.,Heitel, Pascal,Christensen, Kirsten E.,Cooper, Richard I.,Paton, Robert S.,Pomerantz, William C. K.,Biggin, Philip C.,Hammond, Ester M.,Filippakopoulos, Panagis,Conway, Stuart J.
, p. 10102 - 10123 (2021/07/31)
CREBBP (CBP/KAT3A) and its paralogue EP300 (KAT3B) are lysine acetyltransferases (KATs) that are essential for human development. They each comprise 10 domains through which they interact with >400 proteins, making them important transcriptional co-activa
