120386-06-3Relevant articles and documents
Acyclic pyrrolo ?2,3-d!pyrimidine analogs as antiviral agents
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, (2008/06/13)
This invention relates to the use of acyclic substituted pyrrolo?2,3-d!pyrimidine nucleoside analogs in the treatment of viral infections. Such substituted compounds retain antiviral properties present in their parent compounds, yet exhibit significantly decreased levels of cytotoxicity, thereby having therapeutic potential as antiviral agents.
Synthesis and Antivirial Activity of Some Acyclic and C-Acyclic Pyrrolopyrimidine Nucleoside Analogues
Bennett, Sharon M.,Nguyen-Ba, Nghe,Ogilvie, Kelvin K.
, p. 2162 - 2173 (2007/10/02)
A series of acyclic and C-acyclic 7-deazapurine nucleosides have been synthesized and tested for antivirial activity.Reaction of the sodium salt of 2-amino-3,4-bis(aminocarbonyl)-5-(methylthio)pyrrole (6) with an appropriate electrophile gave pyrrole nucl