1204181-95-2Relevant academic research and scientific papers
Bronsted acid catalyzed asymmetric propargylation of aldehydes
Jain, Pankaj,Wang, Hao,Houk, Kendall N.,Antilla, Jon C.
supporting information; experimental part, p. 1391 - 1394 (2012/03/11)
Which gets activated? A versatile and highly enantioselective chiral Bronsted acid catalyzed method for the propargylation of aldehydes is described to provide a range of chiral homopropargylic alcohols. Computational studies support the belief that the c
Synthesis of azide-alkyne fragments for "Click" chemical applications. Part 2. Formation of oligomers from orthogonally protected chiral trialkylsilylhomopropargyl azides and homopropargyl alcohols
Montagnat, Oliver D.,Lessene, Guillaume,Hughes, Andrew B.
supporting information; experimental part, p. 390 - 398 (2010/03/30)
(Chemical Equation Presented) A small library of chiral, β3-substituted homopropargyl alcohols and chiral β3-substituted trimethylsilylhomopropargyl azides were generated starting from natural L-amino acids. The free alkynes and azides were then coupled, using a Huisgen 1,3-dipolar cycloaddition, to provide chiral oligomeric 1,4-disubstituted-1,2,3-triazoles as potential peptidomimetic compounds. The work is an extension to the previous synthesis of racemic, orthogonally protected 1,4-disubstituted-1,2,3-triazoles from the corresponding α-substituted propargyl alcohols and α-substituted trialkylsilylpropargyl azides.
