1204234-60-5

Basic information

• Product Name: 1-(5-broMopyridin-3-yl)-2,2,2-trifluoroethanol
• Synonyms: 1-(5-broMopyridin-3-yl)-2,2,2-trifluoroethanol;3-Pyridinemethanol, 5-bromo-α-(trifluoromethyl)-
• CAS NO: 1204234-60-5
• Molecular Formula: C7H5BrF3NO
• Molecular Weight: 256.03
• Mol File: 1204234-60-5.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(5-broMopyridin-3-yl)-2,2,2-trifluoroethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-broMopyridin-3-yl)-2,2,2-trifluoroethanol(1204234-60-5)
• EPA Substance Registry System: 1-(5-broMopyridin-3-yl)-2,2,2-trifluoroethanol(1204234-60-5)

Safety Data

• Hazardous Substances Data: 1204234-60-5(Hazardous Substances Data)

Usage

General Description

1-(5-bromopyridin-3-yl)-2,2,2-trifluoroethanol is a chemical compound with the molecular formula C7H6BrF3NO. It is a derivative of pyridine, a colorless and flammable liquid, and is commonly used as a reagent in organic synthesis. 1-(5-broMopyridin-3-yl)-2,2,2-trifluoroethanol is a trifluoroethanol derivative with a bromine-substituted pyridine ring, making it useful for various chemical reactions and as an intermediate in the pharmaceutical industry. Its trifluoroethanol group makes it a potent solvent and it is often used in research laboratories and industry settings for its unique chemical properties. As with any chemical, proper handling and precautions should be taken to ensure safe use of 1-(5-bromopyridin-3-yl)-2,2,2-trifluoroethanol.

Upstream product

• 113118-81-3 5-bromopyridine-3-carbaldehyde 
• 81290-20-2 (trifluoromethyl)trimethylsilane 

Downstream Products

• 886364-44-9 1-(5-bromopyridin-3-yl)-2,2,2-trifluoroethan-1-one 

Relevant articles and documents

AZA-HETEROARYL COMPOUNDS AS PI3K-GAMMA INHIBITORS

The present invention provides aza-heteroaryl derivatives of Formula I: and pharmaceutically acceptable salts thereof, wherein X, Y, Z, A, W, R4, R5, and R6 are defined herein, that inhibit the activity of phosphoinositide 3-kinases-gamma (PI3Kγ) and are useful in the treatment of diseases related to the activity of PI3Kγ including, for example, autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

ALDOSTERONE SYNTHASE INHIBITORS

The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2. R3, R4, R5, R6, R7, W, Y, m and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

Highly efficient synthesis of aryl and heteroaryl trifluoromethyl ketones via o-iodobenzoic acid (IBX)

A two-step process for the synthesis of aryl and heteroaryl trifluoromethyl ketones from the corresponding aldehydes is described. Trifluoromethyl alcohols were prepared from aryl and heteroaryl aldehydes in excellent yields using catalytic amount of K2CO3. The trifluoromethyl alcohols were then oxidized conveniently and efficiently by o-iodoxybenzoic acid (IBX) under mild conditions to get the desired functionalized aryl and heteroaryl trifluoromethyl ketones.