1204245-29-3

Usage

Uses

Used in Pharmaceutical Industry:
1,2,3-Trithiane-4-pentanoic acid is used as an intermediate in the synthesis of thioctic acid (α-lipoic acid) for its various pharmaceutical applications. Thioctic acid is a coenzyme involved in the metabolism of carbohydrates, fats, and proteins. It has been widely studied for its potential benefits in treating various health conditions, including diabetes, liver disease, and neurological disorders.
Used in the Process for Preparation of Thioctic Acid with Low Solvent Residue:
1,2,3-Trithiane-4-pentanoic acid is used as a key intermediate in the production of thioctic acid with low solvent residue. This process aims to minimize the environmental impact and improve the safety profile of the final product by reducing the amount of solvents used in the synthesis. The low solvent residue in thioctic acid is particularly important for its use in the pharmaceutical and dietary supplement industries, where purity and safety are paramount.

Upstream product

• 462-20-4 dihydrolipoic acid 
• 1077-28-7 Thioctic acid 
• 1070-64-0 6,8-dichlorooctanoic acid ethyl ester 

Relevant academic research and scientific papers

Preparation method of lipoic acid impurity A

The invention relates to a preparation method of a lipoic acid impurity A, and belongs to the field of compound synthesis. The invention aims to overcome the defects of complex operation and harsh reaction conditions in the prior art, and provides the preparation method of the lipoic acid impurity A. The preparation method is mild in condition and high in product purity. The preparation method comprises the following steps: (1) dissolving lipoic acid in a reaction solvent, adding an oxidant for reaction, and removing solids and the solvent after the reaction is completed to obtain a compound B; (2) respectively adding the compound B, sodium thiosulfate and a catalyst into water, then adding hydrochloric acid, carrying out hydrolysis ring-opening reaction, and filtering after the reaction is completed to obtain a compound C; and (3) respectively adding the compound C, sodium sulfide and formaldehyde into the reaction solvent for reaction, extracting after the reaction is completed, drying, and purifying to obtain a compound D lipoic acid impurity A. The method is mild in condition, and the prepared lipoic acid impurity A is high in purity.

Preparation method of lipoic acid process impurity

The invention relates to a preparation method of a lipoic acid process impurity namely 1,2,3-trithiocyclohexane-4-valeric acid, and belongs to the technical field of preparation of lipoic acid impurities. The preparation method comprises the following steps: carrying out saponification, vulcanization cyclization, acidification, and refining on a lipoic acid intermediate namely 6,8-dichloroethyl caprylate to obtain the product. The preparation method is simple in process, and high in operability and the product is easy to purify.