1204293-83-3Relevant academic research and scientific papers
Asymmetric synthesis of the potent HIV-protease inhibitor, nelfinavir
Raghavan, Sadagopan,Krishnaiah,Sridhar
, p. 498 - 501 (2010)
(Chemical Equation Presented) An asymmetric synthesis of nelfinavir is described starting from acrolein and (S)-methyl phenyl sulfoxide. The key features include (a) stereoselective preparation of a β-protected amino-γ,δ-unsaturated sulfoxide by the reaction of an α-sulfinyl carbanion with an unsaturated t-butyl sulfinylimine, (b) stereoselective bromohydrin formation using the pendant sulfoxide group as an intramolecular nucleophile, and (c) use of commercially or readily prepared inexpensive starting materials.
