1204298-58-7

Basic information

• Product Name: 1-Boc-3-aminoindazole
• Synonyms: 1-Boc-3-aminoindazole;tert-Butyl 3-aMino-1H-indazole-1-carboxylate
• CAS NO: 1204298-58-7
• Molecular Formula: C₁₂H₁₅N₃O₂
• Molecular Weight: 233.2664
• EINECS: 604-604-1
• Product Categories: Building Blocks;Indazole
• Mol File: 1204298-58-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 395.3±34.0 °C(Predicted)
• Appearance: /
• Density: 1.24±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 0.97±0.50(Predicted)
• CAS DataBase Reference: 1-Boc-3-aminoindazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Boc-3-aminoindazole(1204298-58-7)
• EPA Substance Registry System: 1-Boc-3-aminoindazole(1204298-58-7)

Safety Data

• Hazardous Substances Data: 1204298-58-7(Hazardous Substances Data)

Usage

General Description

1-Boc-3-aminoindazole is a chemical compound with the molecular formula C12H17N3O2. It is a derivative of 3-aminoindazole and contains a tert-butoxycarbonyl (Boc) protecting group. 1-Boc-3-aminoindazole is commonly used in organic synthesis as a building block for various pharmaceuticals and functional materials. It has shown potential as an intermediate in the synthesis of biologically active molecules and has been used in the development of new drugs. 1-Boc-3-aminoindazole is known for its stability and its ability to react with a variety of other compounds, making it a valuable tool in the field of medicinal chemistry and drug discovery.

Upstream product

• 870-46-2 t-butoxycarbonylhydrazine 
• 4387-36-4 2-iodobenzonitrile 
• 2042-37-7 o-cyanobromobenzene 
• 24424-99-5 di-tert-butyl dicarbonate 
• 874-05-5 3-aminoindazole 

Relevant articles and documents

Synthesis of aminopyrazole analogs and their evaluation as CDK inhibitors for cancer therapy

We synthesized a library of aminopyrazole analogs to systematically explore the hydrophobic pocket adjacent to the hinge region and the solvent exposed region of cyclin dependent kinases. Structure-activity relationship studies identified an optimal substitution for the hydrophobic pocket and analog 24 as a potent and selective CDK2/5 inhibitor.

Assembly of substituted 3-aminoindazoles from 2-bromobenzonitrile via a CuBr-catalyzed coupling/condensation cascade process

CuBr-catalyzed coupling reaction of 2-halobenzonitriles with hydrazine carboxylic esters and CuBr/4-hydroxy-l-proline-catalyzed coupling reaction of 2-bromobenzonitriles with N′-arylbenzohydrazides proceed smoothly at 60-90 C to provide substituted 3-aminoindazoles through a cascade coupling/condensation (or coupling/deacylation/condensation) process. A wide range of 3-aminoindazoles with substituents at both the 1-position and the phenyl ring part can be prepared from the corresponding coupling partners.