1204298-65-6

Basic information

• Product Name: 5-(difluoromethyl)-1-methyl-1h-pyrazole-4-carboxylic acid
• Synonyms: 5-(difluoromethyl)-1-methyl-1h-pyrazole-4-carboxylic acid;1H-Pyrazole-4-carboxylic acid, 5-(difluoroMethyl)-1-Methyl-
• CAS NO: 1204298-65-6
• Molecular Formula: C₆H₆F₂N₂O₂
• Molecular Weight: 176
• Mol File: 1204298-65-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 315.9±42.0 °C(Predicted)
• Appearance: /
• Density: 1.52
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.12±0.36(Predicted)
• CAS DataBase Reference: 5-(difluoromethyl)-1-methyl-1h-pyrazole-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(difluoromethyl)-1-methyl-1h-pyrazole-4-carboxylic acid(1204298-65-6)
• EPA Substance Registry System: 5-(difluoromethyl)-1-methyl-1h-pyrazole-4-carboxylic acid(1204298-65-6)

Safety Data

• Hazardous Substances Data: 1204298-65-6(Hazardous Substances Data)

Usage

Uses

5-(Difluoromethyl)-1-methyl-1h-pyrazole-4-carboxylic acid is a useful reagent in the preparation of fluxapyroxad analogs which are anti-fungal agents.

InChI:InChI=1S/C6H6F2N2O2/c1-10-4(5(7)8)3(2-9-10)6(11)12/h2,5H,1H3,(H,11,12)

Upstream product

• 851725-87-6 ethyl 3-(dichloromethyl)-1-methyl-1H-pyrazole-4-carboxylate 
• 141573-95-7 ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate 
• 1550-50-1 1,1,2,2-tetrafluoro-N,N-dimethylethan-1-amine 
• 34846-90-7 methyl 3-methoxyprop-2-enoate 
• 60-34-4 methylhydrazine 
• 53927-12-1 ethyl-3-(pyrrolidin-1-yl)prop-2-enoate 
• 1086400-66-9 (Z)-2-(ethoxymethylene)-4,4-difluoro-3-oxobutanoic acid ethyl ester 

Relevant articles and documents

Preparation method for polyfluoromethylpyrazole compound, and intermediate of compound and preparation method thereof

The invention discloses a preparation method for a polyfluoromethylpyrazole compound, and an intermediate of the compound and a preparation method thereof. The invention provides a preparation method for a compound 1 as defined in the specification. The preparation method comprises a step of subjecting a compound 2 as defined in the specification and methylhydrazine to a ring-closure reaction in an organic solvent so as to obtain the compound 1, wherein R is a C1-4 alkyl group, R is a methyl or ethyl group and x is 2 or 3. The preparation method provided by the invention uses cheap and easily available raw materials and is mild in reaction conditions, safe to operate, environment friendly, low in production cost, high in reaction conversion rate, low in the content of isomer in by-products, high in reaction yield and product purity and suitable for industrial production.

Method for Producing Difluoromethyl-Substituted Pyrazole Compounds

The present invention relates to a process for preparing 3-difluoromethyl-substituted pyrazole compounds of the formula (I) in which R1 is H, halogen, nitro, C1-C8-alkyl, C1-C8-haloalkyl, C3-C8-cycloalkyl, phenyl, naphthyl, hetaryl, cyano, —C(=O)—OR1a, —C(=O)—NR1bR1c, —C(=O)—SR1d or —C(=S)—SR1e; R2 is H, C1-C4-alkyl, benzyl or phenyl; R3 is H, halogen, C1-C8-alkoxy, C1-C8-haloalkoxy, C3-C8-cycloalkoxy, C2-C8-alkenyloxy, C1-C8-alkylthio, C1-C8-haloalkylthio, C3-C8-cyclo-alkylthio or C2-C8-alkenylthio; compounds of the formula (II.a) or (II.b), in which R1 and R3 each have one of the definitions given above; R4 is halogen, —OR4a, —SR4a, —O—SO2—R4a or an —NR4bR4c group; R5 and R6 are each C1-C8-alkyl, C1-C8-haloalkyl, C3-C8-cycloalkyl, benzyl or phenyl, or, together with the nitrogen atom to which they are bonded, are a 3- to 8-membered heterocycle; Lewis acid adducts of compounds of the formula (II.b); the use of compounds of the formula (II.a) or (II.b) and of the Lewis acid adducts for preparing compounds of the formula (I) or (VI); and to a process for converting such compounds to the corresponding 3-difluoro-pyrazol-4-ylcarboxylic acids.